肾脏肿瘤患者CT灌注参数与肾功能生化检测指标的相关性研究  

Study on the Correlation Between CT Perfusion Parameters and Renal Function Biochemical Indexes in Patients with Renal Tumor

作　　者：张锋 徐英进[2] 魏巍[3] 王旭光 辛伟凡 李博 ZHANG Feng;XU Ying-jin;WEI Wei;WANG Xu-guang;XIN Wei-fan;LI Bo(Department of Radiology,Hebei Mental Health Center/The Sixth People＇s Hospital of Hebei Province,Baoding,Hebei,071000,China;CT Room,Affiliated Hospital of Hebei University,Baoding,Hebei 071000,China;Department of Radiology,Rongiun Hospital of Hebei Province,Baoding,Hebei,071000,China)

机构地区：[1]河北省精神卫生中心/河北省第六人民医院放射科,河北保定071000 [2]河北大学附属医院CT室,河北保定071000 [3]河北省荣军医院放射科,河北保定071000

出　　处：《现代生物医学进展》2018年第16期3153-3156,共4页Progress in Modern Biomedicine

基　　金：河北省卫生厅医学科学研究项目(20130408)

摘　　要：目的:探讨肾脏肿瘤患者CT灌注参数与肾功能生化检测指标的相关性。方法:选取河北省第六人民医院2013年3月至2018年1月期间收治的35例肾脏肿瘤患者作为观察组,另选取同期来我院体检的35例健康者作为对照组,均对两组受试者实施CT灌注成像,获取等效血容量(Equiv BV)、表面渗透性(Ps)、血流量(BF)等CT灌注参数,并检测两组受试者血尿素氮(BUN)、血肌酐(Scr)、总胆固醇(TC)、甘油三酯(TG)等肾功能生化指标,对比两组受试者上述指标检测结果,采用Pearson相关分析CT灌注参数与肾功能生化指标的相关性。结果:与对照组相比,观察组CT灌注参数Equiv BV、Ps、BF均降低,肾功能生化指标BUN、Scr、TC、TG水平均升高,有统计学差异(P<0.05)。Pearson相关分析结果显示,CT灌注参数Equiv BV、Ps、BF与肾功能生化指标TC、BUN均呈负相关(P<0.05),与Scr、TG无相关性(P>0.05)。结论:肾脏肿瘤患者的CT灌注参数Equiv BV、Ps、BF均较低,BUN、Scr、TC、TG水平均较高,且CT灌注参数与BUN、TC水平呈负相关性,可作为评估肾脏肿瘤患者肾功能的辅助方法。Objective： To investigate the correlation between CT perfusion parameters and renal function biochemical indexes in patients with renal tumor. Methods： 35 patients with renal tumor ine from March 2013 to January 2018 were selected as the observation group,another 35 healthy persons who were admitted to The Sixth People＇s Hospital of Hebei Province during the same period were selected as control group. CT perfusion imaging was performed in two groups,and CT perfusion parameters such as equivalent blood volume（Equiv BV）,permeability surface（Ps）,blood flow（BF） were obtained. The renal function biochemical indexes such as blood urea nitrogen（BUN）,serum creatinine（Scr）,total cholesterol（TC） and triglyceride（TG） were detected in two groups,and the results of the above indexs in two groups were compared. The correlation between CT perfusion parameters and renal function biochemical indexes was analyzed by Pearson correlation analysis. Results： Compared with the control group,the CT perfusion parameters such as Equiv BV,Ps and BF in the observation group were all decreased,and the levels of renal function biochemical indexes such as BUN,Scr,TC and TG were all increased,the differences were statistically significant（P〈0.05）. Pearson correlation analysis showed that CT perfusion parameters such as Equiv BV,Ps and BF were negatively correlated with renal function biochemical indexes TC and BUN（P〈0.05）,but not correlated with Scr and TG（P〉0.05）. Conclusion： CT perfusion parameters such as Equiv BV,Ps and BF of renal tumor patients were lower,and the levels of BUN,Scr,TC and TG were higher. CT perfusion parameters are negatively correlated with the levels of BUN and TG,which can be used as an auxiliary method to evaluate renal function in patients with renal tumor.

关 键 词：肾脏肿瘤 CT灌注参数 肾功能 生化检测指标 相关性 

分 类 号：R737.11[医药卫生—肿瘤]