西藏、四川藏汉族健康人群Helicobacter pylori感染情况比较  

A comparative study on Helicobacter pylori infection in Tibetan and Han people from Tibet and Sichuan province

作　　者：陈茉 刘超[1] 宦徽 胡仁伟[2] 吴浩[2] 邓凯 Mo Chen;Chao Liu;Hui Huan;Ren-Wei Hu;Hao Wu;Kai Deng(Department of Gastroenterology,Tibetan Chengdu Branch of West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China;Department of Gastroenterology.West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China)

机构地区：[1]四川大学华西医院西藏成办分院消化内科,四川省成都市610041 [2]四川大学华西医院消化内科,四川省成都市610041

出　　处：《世界华人消化杂志》2018年第23期1402-1407,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金青年项目;No.81600511;四川大学青年启动基金;No.2017SCU11073~~

摘　　要：目的比较分析西藏和四川地区藏幽门螺杆菌(Helicobacter pylori,H.pylori)感染的情况.方法检索西藏成办分院及华西医院接受14C呼气试验检查的体检者,筛选来自西藏和四川地区的藏汉族体检资料,并收集临床资料、常居留地、H.pylori检测结果等.结果西藏和四川地区分别纳入藏汉族体检者547/297和308/1011例,其总体H.pylori阳性率西藏明显高于四川(50.8%/39.3%,P<0.001).西藏和四川地区的藏族健康人群H.pylori阳性率均高于汉族(56.9%/39.7%,P<0.001;52.3%/35.4%,P<0.001).藏族和汉族健康人群H.pylori阳性率在西藏与四川地区之间无差异(P=0.196和P=0.192).高龄组的H.pylori阳性率在汉族健康人群中出现升高,而在藏族健康人群中出现降低(年龄<45 vs年龄≥45:32.3%/40.5%,P=0.002;61.5%/50.0%,P=0.001).结论西藏与四川地区藏汉族健康人群的H.pylori感染情况相似,均为藏族高于汉族.汉族健康人群H.pylori感染与年龄正相关,而藏族健康人群却相反.AIM To compare the prevalence of Helicobacter pylori（H. pylori） infection in Tibetan and Han subjects from Tibet and Sichuan province.METHODS A retrospective study for investigating H. pylori infection was performed among Tibetan and Han subjects who underwent the 14 C-urea breath test at the Tibetan Chengdu Branch Hospital and West China Hospital. The clinical characteristics（residential address, H. pylori infection status, etc.） were collected and recorded.RESULTS A total of 2163 subjects from Tibet（Tibetan/Han, 547/297） and Sichuan province（Tibetan/Han, 308/1011） were enrolled in this retrospective study. The overall H. pylori positive rate in Tibet was significantly lower than that in Sichuan province（50.8% vs 39.3%, P 0.001）. The H. pylori positive rate in Tibetan subjects from both Tibet and Sichuan was significantly higher than that in Han people（56.9% vs 39.7%, P 0.001; 52.3% vs 35.4%, P 0.001）. No significant difference was observed in the H. pylori positive rate between Tibetan subjects from Tibet and Sichuan（P = 0.196） or Han subjects from Tibet and Sichuan（P = 0.192）. The H. pylori positive rate of Han ethnic subjects significantly increased in the older age group（age 45 vs age ≥ 45： 32.3% vs 40.5%, P = 0.002）. However, the H. pylori positive rate of Tibetan subjects significantly decreased in the older age group（age 45vs age ≥ 45： 61.5% vs 50.0%, P = 0.001）.CONCLUSION The H. pylori prevalence rate is higher in Tibetan subjects than in Han subjects from Sichuan province and Tibet. The H. pylori prevalence rate is positively correlated with age in Han subjects, but is negatively correlated with age in Tibetan subjects.

关 键 词：幽门螺杆菌感染 藏族 四川 藏区 年龄 

分 类 号：R57[医药卫生—消化系统]