治疗时间对氯胺酮抗抑郁作用影响的研究概况及未来展望  

Effect of treatment time on antidepressant effect of ketamine: current research status and future directions

作　　者：李申[1,2] 李洁[1] 田红军 Albert Leemon Walter Martin 禚传君 Li Shen;Li Jie;Tian Hongjun;Albert Leemon;Walter Martin;Zhuo Chuanjun(Tianjin Mental Health Research Institute,Tianjin Mental Health Center,Anding Hospital Affiliated to Nankai University,Tianjin 300222,China;Department of Psychiatry,Tianjin Medical University,Tianjin 300070,China;Clinical Affective Neuroimaging Laboratory,Otto yon Guericke University,Magdeburg 39120,Germany;Department of Psychiatry and Psychotherapy,University of Tubingen,Tubingen 3917,Germany)

机构地区：[1]天津医科大学精神卫生研究所天津市精神卫生中心南开大学附属安定医院,300222 [2]天津医科大学精神卫生学系,300070 [3]Clinical Affective Neuroimaging Laboratory,Otto von Guericke University [4]Department of Psychiatry and Psychotherapy,University of Tübingen [5]温州市第七人民医院,325000

出　　处：《中华诊断学电子杂志》2018年第3期151-156,共6页Chinese Journal of Diagnostics(Electronic Edition)

基　　金：德国国家自然科学基金(DFG-SFB779);天津市自然科学重点基金(17JCZDJC35700);天津市卫计委重点基金(2014KR02)

摘　　要：抑郁障碍是一种常见的严重精神疾病,具有高致残率和致死率,给社会和家庭造成严重负担。目前,近一半抑郁症患者无法得到有效的治疗。在临床实践中,可以广泛观察到氯胺酮具有明显缓解抑郁症状的作用,然而对其抗抑郁机理的研究尚不明确。笔者主要着眼于氯胺酮抗抑郁作用机理的相关研究进展,重点关注氯胺酮抗抑郁作用的短暂急性期和持续的延迟期机制的复杂相互作用的生物学基础,根据已有文献和前期研究结果提出可行的预设方案,旨在为氯胺酮抗抑郁作用的临床应用提供科学依据。Depressive disorder is a common serious mental illness,with significant disability rate and mortality,which has caused serious burden to society and family. At present,nearly half of the depressive patients are unable to get effective treatment. In clinical practice,ketamine was widely observed to alleviate depressive symptoms effectively. However,its antidepressant mechanism is not clear. Focusing on the progresses in antidepressive mechanism of ketamine,this review summarizes the complex interaction mechanism about acute and delayed effect of ketamine,and puts forward the feasible scheme of design based on the existing literatures and previous researches, which aims to provide scientific basis for clinical application of ketamine as an antidepressant.

关 键 词：氯胺酮 抑郁症 时间 N-甲基-D-天冬氨酸受体 

分 类 号：R749.4[医药卫生—神经病学与精神病学]