宫颈上皮内瘤变患者宫颈病原菌感染及HR-HPV感染情况分析  

Prevalence of cervical pathogenic bacteria infections and HR-HPV infections in CIN

作　　者：钟汇 邱华红[1] 饶冬东[1] 董滨华[2] 徐两蒲[1] ZHONG Hui;QIU Huahong;RAO Dongdong;DONG Binghua;XU Liangpu(Department of Clinical Laboratory,Fujian Provincial Maternity and Children＇s Health Hospital,Fuzhou,Fujian 350001,China)

机构地区：[1]福建省妇幼保健院检验科,福州350001 [2]福建省妇幼保健院妇科肿瘤实验室,福州350001

出　　处：《福建医药杂志》2018年第4期1-3,共3页Fujian Medical Journal

基　　金：福建省自然科学基金(2017J01232)

摘　　要：目的探讨宫颈上皮内瘤变(CIN)患者宫颈分泌物病原菌感染与HR-HPV感染的关系。方法选择245例我院入院就诊且病理确诊为CIN的患者为观察组(CINⅢ级85例、CINⅡ级75例,CINⅠ级85例),另选200例宫颈上皮正常者为对照组,对两组患者宫颈分泌物行病原菌培养及HPV-DNA检测。结果观察组病原菌阳性率33.5%、对照组病原菌阳性率为16.0%,观察组病原菌阳性率高于对照组(P<0.05);CINⅢ级、CINⅡ级病原菌阳性率分别为41.2%、36.0%,均高于对照组(P<0.05);CINⅠ级的病原菌阳性率与对照组比较差异无统计学意义(P>0.05);CIN组与对照组病原菌菌群分布差异无统计学意义(P>0.05);观察组和对照组HR-HPV阳性患者宫颈分泌物病原菌培养情况的差异有统计学意义(P<0.05)。结论宫颈病原菌感染对HR-HPV导致的CIN可能存在辅助协同作用。Objective To investigate the relationship between HR-HPV infection and pathogenic bacterial infection in CIN patients.Methods A total of 245 patients that pathologically confirmed as CIN served as an experimental group,and 200 patients with normal cervical epithelium served as a control group.Patients in two groups all received cervical secretions regular bacterial culture and HPV-DNA testing.Results The infection rate of pathogenic bacteria in CIN was 33.5%,higher than the control group which the infection rate was 16.0% and the difference was statistically significant（P〈0.05）.The infection rate of pathogenic bacteria in CINⅢ group and CINⅡ group were 41.2% and 36.0% respectively,higher than the control group,and the difference was statistically significant（P〈0.05）.Compared the infection rate of pathogenic bacteria betweent CINI group and control group,the difference had no statistical significance（P〉0.05）.The flora distribution was no difference between the CIN group and the control group.The pathogenic bacterial culture results of HR-HPV-positive patients in two group were statistically different（P〈0.05）.Conclusion Pathogenic baterial infection may be an efficient cofactor for HR-HPV to cause CIN.

关 键 词：宫颈上皮内瘤变 病原菌 高危型人乳头瘤病毒 

分 类 号：R737.33[医药卫生—肿瘤]