普罗布考联合尼莫同治疗脑梗死合并血管性认知障碍疗效分析  

Efficacy of Probucol combined with NiMo in the Treatment of Cerebral Infarction Accompanied with Vascular Cognitive Impairment

作　　者：张庆梅[1] 陈枫[1] 曹辉[1] 苏俊红[1] 倪文[2] ZHANG Qing-mei;CHEN Feng;CAO Hui;SUN Jun-hong;NI Wen(Neurology department,The People＇s Hospital of Xinjiang Shihezi,Xinjiang Shihezi,832000;Neuroelec-trophysiological department,People＇s Hospital of Xinjiang Shihezi,Xinjiang Shihezi 832000)

机构地区：[1]新疆石河子市人民医院神经内科,新疆石河子832000 [2]新疆石河子市人民医院神经电生理室,新疆石河子832000

出　　处：《农垦医学》2018年第3期225-228,共4页Journal of Nongken Medicine

摘　　要：目的:探讨普罗布考联合尼莫同治疗脑梗死合并血管性认知障碍疗效。方法:116例合并认知功能障碍的脑梗死患者随机分为两组,对照组采用尼莫同治疗,实验组采用尼莫同联合普罗布考治疗。治疗前及治疗6个月后分别检测:血脂、CRP,行NIHSS、MMSE、Mo CA、BI指数评分。结果:治疗6个月后,(1)两组患者CRP、TC、TG、LDL-C均降低,HDL-C均增加,差异有统计学意义(P<0.05),实验组治疗后CRP、TC、TG、LDL-C低于对照组,HDL-C高于对照组,差异有统计学意义(P<0.05);(2)两组患者较治疗前NIHSS评分降低,MMSE评分、Mo CA评分增加,差异有统计学意义(P<0.05),实验组治疗后NIHSS评分低于对照组,MMSE评分、Mo CA评分高于对照组,差异有统计学意义(P<0.05);(3)两组患者BI指数较治疗前评分提高,差异有统计学意义(P<0.05),实验组治疗后BI评分高于对照组,差异有统计学意义(P<0.05)。结论:普罗布考联合尼膜同治疗,可改善脑梗死患者肢体残疾及认知功能障碍,值得临床推广。Objective： To probe into the efficacy of probucol combined with NiMo in the treatment of cerebral infarction with vascular cognitive impairment.Methods： 116 patients with cerebral infarction with cognitive impairment were randomly divided into 2 groups.The control group was treated with NiMo, and the experimental group was treated with NiMo and probucol.Pretherapy and after six months, the blood lipid and CRP were measured, and the scores of NIHSS, MMSE, MoCA and BI were scored.Results： After six months, （1）the two groups of patients with CRP, TC, TG and LDL-C all decreased, and HDL-C increased. The difference was statistically significant（P〈0.05）.The CRP, TC, TG and LDL-C in the experimental group were lower than those of the control group, and the HDL-C was higher than the control group. The difference was statistically significant（P〈0.05）.（2） The NIHSS scores of the two groups were lower than those before the treatment. The MMSE score and the MoCA score increased in the two groups, and the difference was statistically significant（P〈0.05）.The NIHSS score of the experimental group was lower than that of the control group. The MMSE score and the MoCA score were higher than the control group. The difference was statistically significant（P〈0.05）.（3） The BI index of the two groups was higher than that before the treatment, and the difference was statistically significant（P〈0.05）.The score of BI in the experimental group was higher than that of the control group, and the difference was statistically significant（P〈0.05）.Conclusion：Cerebral infarction patients with probucol combined with nimodipine can improve limb disability and cognitive dysfunction, which is worthy of clinical promotion.

关 键 词：普罗布考 脑梗死 认知功能障碍 

分 类 号：R743.3[医药卫生—神经病学与精神病学]