肠道淤血再灌注对肠黏膜及肝脏损伤的研究进展  

Research Progress of Intestinal Congestion-Reperfusion on Intestinal Mucosa and Liver Injury

作　　者：赵霜艳 马莉[1] 陈文栋[1] ZHAO Shuangyan;MA Li;CHEN Wendong(Department of Anesthesiology,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院麻醉科,昆明650032

出　　处：《医学综述》2018年第17期3403-3408,共6页Medical Recapitulate

基　　金：昆明医科大学第一附属医院博士科研基金(2015BS022);云南省卫生科技计划项目(2017NS044)

摘　　要：肝移植作为治疗终末期肝病的有效手段,目前较为成熟的方式为背驮式。术中在切除受体的病肝前需夹闭门静脉,使肠道血液回流受阻发生淤血,而在植入供体肝后门静脉开放,肠道血流恢复导致肠道淤血再灌注损伤。淤血再灌注损伤是肝移植术后常见的并发症,淤血再灌注所造成的危害较缺血/再灌注更严重,但现阶段对肝移植引起淤血再灌注损伤的内在机制并不清楚,故缺乏有效治疗措施。肠道淤血再灌注不仅对肠黏膜有损伤,还可加重肝脏的缺血/再灌注损伤。未来,研究肠道淤血再灌注对肠道本身及肝脏的损伤,将为肠道淤血再灌注损伤的防治提供新思路。The more mature approach for liver transplantation,which is an effective treatment for end-stage liver disease,is the piggback approach at present.During the operation,the portal vein needs to be occluded before the diseased liver of the recipient is resected,which makes the intestinal blood flow block and congestion occur,and opening the portal vein leads to the intestinal congestion-reperfusion injury after implantation of the donor＇s liver.Congestion-reperfusion injury is a common complication after liver transplantation,and the damage caused by congestion-reperfusion is more serious than ischemia/reperfusion.However,the underlying mechanism of congestion-reperfusion injury caused by liver transplantation is not clear at this stage,so there is no effective treatment.Intestinal congestion-reperfusion not only damages the intestinal mucosa,but also aggravates hepatic ischemia/reperfusion injury.In the future,study on the intestinal congestion-reperfusion damage to the intestinal mucosa and the liver will provide new ideas for the prevention and treatment.

关 键 词：肠黏膜损伤 肝脏损伤 肠道淤血再灌注 

分 类 号：R574[医药卫生—消化系统]