EphrinA2和EphA7在前列腺癌中的表达及临床意义  

Expression and Clinical Significance of EphrinA2 and EphA7 in Prostate Cancer

作　　者：陈放 熊玮 杜杨春 钟山 吕骥 郭璞 冉清 窦科 CHEN Fang;XIONG Wei;DU Yang-chun;ZHONG Shan;LYU Ji;GUO Pu;RAN Qing;DOU Ke(Organ Transplantation Center,Sichuan Academy of Medical Science Sichuan Provincial People＇s Hospital,Chengdu 610072,China;Department of Urology,Sichuan Academy of Medical Science and Sichuan Provincial People＇s Hospital,Chengdu 610110,China)

机构地区：[1]四川省医学科学院四川省人民医院器官移植中心,成都610072 [2]四川省医学科学院四川省人民医院城东病区泌尿男科,成都610110

出　　处：《临床误诊误治》2018年第9期59-63,共5页Clinical Misdiagnosis & Mistherapy

基　　金：四川省科技厅基金资助(2014SZ0011)

摘　　要：目的观察EphrinA2和EphA7在前列腺癌中的表达情况及其与临床病理特征、预后的相关性。方法选取我院2010年5月—2012年12月收治的68例前列腺癌标本(观察组)及68例癌旁正常前列腺组织(对照组),检测EphrinA2和EphA7的表达情况,记录所有患者的性别、年龄、肿瘤及预后等情况。结果观察组EphrinA2和EphA7表达水平显著高于对照组,差异有统计学意义(P<0.05)。不同肿瘤分化程度、临床分期及是否出现骨转移和淋巴结转移的前列腺癌患者EphrinA2和EphA7的表达水平差异有统计学意义(P<0.05)。EphrinA2表达阳性和非阳性的5年总生存率分别为27.03%(10/37)、45.16%(14/31),EphA7表达阳性和非阳性的5年总生存率分别为25.00%(8/32)、44.44%(16/36),差异均有统计学意义(P<0.05)。多因素Cox比例风险回归模型分析显示,肿瘤分化程度、临床分期、出现骨转移和淋巴结转移及EphrinA2和EphA7表达阳性均为影响前列腺癌预后的独立危险因素(P<0.05)。结论肿瘤分化程度、临床分期、出现骨转移和淋巴结转移及EphrinA2和EphA7表达阳性均为影响前列腺癌预后的独立危险因素,且EphrinA2和EphA7表达情况可作为评估病情进展和预后的有效指标。Objective To observe the expression of EphrinA2 and EphA7 in prostate cancer and its correlation with clinicopathological features and prognosis. Methods A total of 68 specimens of prostate cancer （observation group） and 68 adjacent normal prostate tissues （control group） were collected from the patients who were admitted to our hospital from May 2010 to December 2012. The expressions of EphrinA2 and EphA7 were detected, and sex, age, tumor and prognosis of all the patients were recorded. Results The expression levels of EphrinA2 and EphA7 in the observation group were significantly higher than those in the control group （ P 〈0.05）. There was significant difference in the expression of EphrinA2 and EphA7 in patients with different degrees of tumor differentiation, clinical stages, bone metastasis and lymph node metastasis （ P 〈0.05）. The 5-year survival rates of patients with positive and non-positive expression of EphrinA2 were 27.03% （10/37） and 45.16% （14/31） respectively. The 5-year survival rates of patients with positive and non-positive expression of EphA7 were 25% （8/32） and 44.44% （16/36） respectively, and the difference was statistically significant （ P 〈0.05）. Multivariate Cox proportional hazard regression analysis showed that tumor differentiation, clinical stages, bone metastasis and lymph node metastasis, and positive EphrinA2 and EphA7 expression were independent risk factors for the prognosis of prostate cancer （ P 〈0.05）. Conclusion Tumor differentiation, clinical stages, bone metastasis and lymph node metastasis, and positive expressions of EphrinA2 and EphA7 are independent risk factors for the prognosis of prostate cancer, and the expression of EphrinA2 and EphA7 can be used as an effective index to evaluate the progression and prognosis of the disease.

关 键 词：前列腺肿瘤 受体 Eph家族 预后 危险因素 

分 类 号：R737.25[医药卫生—肿瘤]