非甾体抗炎药相关消化性溃疡出血患者的临床特征分析  

Clinical characteristics of patients with peptic ulcer bleeding associated with non-steroidal anti-inflammatory drugs

作　　者：谭峥嵘[1] 张清[1] 彭琴 汪小英 TAN Zheng-rong;ZHANG Qing;PENG Qin;WANG Xiao-ying(Department of Gastroenterology;Pharmacy Department,The second people＇s Hospital,The Three Gorges University,Yichang Second Peopled Hospital,Yichang 443000 9China)

机构地区：[1]三峡大学第二人民医院.湖北省宜昌市第二人民医院消化内科,湖北宜昌443000 [2]三峡大学第二人民医院.湖北省宜昌市第二人民医院药剂科,湖北宜昌443000

出　　处：《实用医院临床杂志》2018年第5期70-72,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨非甾体抗炎药(NSAIDs)相关消化性溃疡出血患者的临床特征,为临床预防消化性溃疡出血提供参考。方法对154例消化性溃疡出血患者进行回顾性分析,根据患者出血前1周是否服用NSAIDs药物,分为NSAIDs组(n=41)和非NSAIDs组(n=113),比较两组性别、年龄、基础疾病、临床特征及胃镜表现等临床资料。结果 NSAIDs组年龄≥60岁、合并心脑血管疾病史、出血量≥1000 ml患者比例高于非NSAIDs组,十二指肠溃疡患者比例低于非NSAIDs组,同时两组患者出血前消化道症状和胃镜检查结果差异均有统计学意义(P<0.05)。结论 NSAIDs相关性溃疡出血患者临床特征主要为高龄、合并心脑血管疾病、发病隐匿,无明显的腹痛症状,出血量较大。Objertive To investigate the clinical characteristics of patients with non-steroidal anti-inflammatory dmgs （NSAIDs） associated peptic ulcer bleeding in order to provide the references for clinical prevention of the disease.Methods Clinical data of 154 patients with peptic ulcer bleeding were retrospectively angilyzed.The patients were divided into NSAIDs group （n= 41 ） and non-NSAIDs group （n= 113） according to whether or not the patients took NSAIDs before one week of bleeding.The clinical data such as sex, age, basic diseases, clinical features and gastroscopic findings were compared between the two groups.Results The pro-portions of patients with age ≥60 years old,history of cardiovascular and cerebrovascular diseases and bleeding volume ≥1,000 ml in the NSAIDs group was significandy higher than those in the non-NSAIDs group while the proportion of patients with duodenal ulcer was lower in the NSAIDs group than that in the non-NSAIDs group.Moreover,the differences in gastroscopic findings and gastrointestinal symptoms before bleeding were statistically significant （ P 〈0.05 ） . Conclusion The main risk factors for NSAIDs-related ulcer bleed-ing were advanced age, cardiovascular and cerebrovascular diseases, and peptic ulcer disease.The clinical features of patients with NSAIDs-related ulcer bleeding were mainly occult onset,no obvious symptoms of abdominal pain and large bleeding.

关 键 词：非甾体类抗炎药 消化性溃疡出血 临床特征 

分 类 号：R573.1[医药卫生—消化系统]