基于射野区域剂量验证新算法的研究与应用  

The research and application of new algorithm based on dose verification of beam region

作　　者：胡兴刚 徐家云[1] 郞锦义 尹刚[2] HU Xinggang;XU Jiayun;YIN Gang;LANG Jinyi(College of Physical Science and Technology,Sichuan U niversity,Chengdu 610064,China;Department of Radiation On cology,Sichuan Cancer Hospital,Chengdu 610041,China)

机构地区：[1]四川大学物理科学与技术学院,四川成都610064 [2]四川省肿瘤医院放疗中心,四川成都610041

出　　处：《西部医学》2018年第9期1269-1277,共9页Medical Journal of West China

基　　金：四川省重点研发计划(2017SZ0004)

摘　　要：目的对病人放射治疗计划的质量保证(QA),重新定义并计算gamma(γ)通过率(%GP),统计分析靶区剂量冷点和危及器官的剂量热点。方法随机选取6例调强放射治疗(IMRT)计划并匿名纳入本研究,从治疗计划系统(TPS)中输出DICOM文件。在等中心平面重建感兴趣区域(ROI)轮廓和相应剂量,用与模体中实际测量值进行分析,新方法以射野区域为计算区域,并统计靶区剂量冷点与危及器官剂量热点,利用剂量面积直方图(DMH)评估TPS的准确性。结果传统方法的通过率受计算区域(阈值)选择影响较大,而新方法不受阈值选择的影响,且能得到靶区和正常器官各自的验证情况,能够提供更多的临床信息。结论新方法实现了%GP的临床可解释,使评估更贴合临床评估,能够更好的发现治疗计划是否存在问题,更好的指导临床工作。Objective The aim of this work is that quality assurance（QA）were performed for all patients＇ plans by the redefinition of the gamma（γ）passing rate（%GP）,and the statistical analysis of dose paint hot of the target and of cold dose spots of OARs.Methods 6 patients of intensity-modulated radiotherapy（IMRT）treatment plans were chosen for the purpose of this study.DICOM files exported from treatment planning system（TPS）were loaded on the software MATLAB.The reconstructed 2 Ddose distribution from the software MATLAB was compared with that for a TPS and the measured dose distribution by use of the MatriXX.For the new method,we select the beam flux region as computational region（CR）,the statistical analysis of dose paint hot of the target and of cold dose spots of OARs,the introduction of a dose-area histogram（DAH）was used to assess the clinical accuracy of TPS.Results The%GP of the traditional method was greatly influenced by the CR（threshold value）,but the new method was not influenced by threshold selection,and that the new methods could obtain the dose verification of target and OARs respectively,while providing significantly more additional clinic information.Conclusion The aim of this paper was to achieve clinical interpretability of the%GP,and making the gamma evaluation more closely fit the clinical assessment.It was able to better find the issue that has been identified for treatment planning,and make better guidance for the clinical work.

关 键 词：剂量验证 通过率 剂量冷点 剂量热点 

分 类 号：R730.55[医药卫生—肿瘤]