椎体成形术联合双膦酸盐治疗恶性肿瘤椎体转移的临床研究  

Clinical study of percutaneous vertebroplasty combined with bisphosphonates for vertebral malignant tumor

作　　者：黄磊 刘丽[2] 程良 谭光根 罗文中 李波 HUANG Lei;LIU Li;CHENG Liang;TAN Guanggen;LUO Wenzhong;LI Bo(Department of Orthopedic,The 6th People＇s Hospital of Chongqing,Chongqing 400060,Chian;Department of Oncology,The 5th People＇s Hospital of Chongqing,Chongqing 400062,China;Department of General Surgery;Chinese Medicine Hospital of Nanchong,Nanchong 637000,Sichuan,China)

机构地区：[1]重庆市第六人民医院骨科,重庆400060 [2]重庆市第五人民医院肿瘤科,重庆400062 [3]南充市中医医院普外科,四川南充637000

出　　处：《西部医学》2018年第9期1283-1287,共5页Medical Journal of West China

基　　金：重庆市南岸区科委计划项目([2014]7);南充市研发资金项目(14A0073)

摘　　要：目的观察经皮椎体成形术(Percutaneous vertebroplasty,PVP)联合双膦酸盐治疗恶性肿瘤椎体转移的临床疗效。方法将32例恶性肿瘤椎体转移患者分为观察组17例和对照组15例,观察组患者采用PVP联合双膦酸盐治疗,对照组患者采用双膦酸盐治疗;对比观察两组患者治疗后的临床疗效。结果观察组与对照组24小时、1周、1个月和3个月疼痛缓解的优良率、有效率比较差异无统计学意义(P>0.05);观察组与对照组6个月、12个月和24个月疼痛缓解的优良率、有效率比较差异有统计学意义(P<0.05)。观察组与对照组24小时、1周、1个月、3个月和6个月生活质量改善情况比较差异无统计学意义(P>0.05);观察组与对照组12个月和24个月生活质量改善情况比较差异有统计学意义(P<0.05)。结论 PVP联合双膦酸盐治疗恶性肿瘤椎体转移疗效好,能有效减轻患者的骨痛、改善患者的生活质量,且PVP操作简单、安全性高,患者耐受性也好。Objective To research the efficacy of percutaneous PVP combined with bisphosphonates for vertebral malignant tumor.Methods 32 patients with vertebral malignant tumor were divided into observation group and control group.The observation group was treated with PVP plus bisphosphonates regimen.The control group was treated with bisphosphonates regime alonely.Efficacy of the two groups were observed and compared.Results At 24 th hour,1 th week,1 th month and 3 rd month after treatment,the excellent rate and effective rate of pain relief between the two groups were not statistically different（P〉0.05）.While at 6 th month,12 th month and 24 th month after treatment,the two indexes were statistically different（P〈0.05）.At 24 th hour,1 th week,1 th month,3 rd month and 6 th month after treatment,the quality of life between the two groups was no statistically difference（P〉0.05）;and the index was statistically different（P〈0.05）.Conclusion PVP combined with bisphosphonates could effectively treat vertebral malignant tumor,which could effectively alleviate the patient＇s bone pain and improved the quality of life of patients.Besides,the operation procedures of PVP are simple and safe,which can be easily accepted by patients.

关 键 词：经皮椎体成形术 双膦酸盐 恶性肿瘤 椎体转移癌 

分 类 号：R738[医药卫生—肿瘤]