左旋甲状腺素片对老年甲状腺癌患者的临床疗效及对血清sIL-2R CD44V6 TSGF水平及p27表达的影响  

Effect of Levothyroxine Tablet on Serum sIL-2R CD44V6 TSGF Levels and p27 Expression in Elderly Patients with Thyroid Carcinoma

作　　者：胡锟[1] 李春燕[1] 童彦初[1] HU Kun;LI Chunyan;TONG Yanchu(Jingzhou Central Hospital,Hubei Jingzhou 434020,China)

机构地区：[1]湖北省荆州市中心医院普外科,湖北荆州434020

出　　处：《河北医学》2018年第9期1437-1440,共4页Hebei Medicine

基　　金：湖北省基金项目;(编号:EK110052)

摘　　要：目的:研究左旋甲状腺素片对老年甲状腺癌患者的临床疗效及对血清s IL-2R、CD44V6、TSGF水平及p27表达的影响。方法:选取我院2014年6月至2017年6月收治的老年甲状腺癌患者106例,采用简单随机分组法将其分为对照组和观察组,每组各53例。对照组患者接受甲状腺素替代疗法治疗,观察组患者口服左旋甲状腺素片治疗,均连续治疗1个月。比较两组患者治疗前后的血清可溶性白细胞介素-2受体(s IL-2R)、白细胞分化抗44变异型(CD44V6)、肿瘤特异性生长因子(TSGF)、T淋巴细胞亚群水平及甲状腺癌组织中p27蛋白表达阳性率。结果:治疗后,观察组的血清s IL-2R、CD44V6、TSGF水平分别为(378.65±30.14)μ/m L、(310.84±21.78)ng/m L、(58.86±6.78)μ/m L,均明显低于对照组[(436.90±33.72)μ/m L、(382.43±26.06)ng/m L、(62.73±7.40)μ/m L](P<0.01),血CD3+、CD4+水平分别为(67.02±8.31)和(27.56±4.27),均明显高于对照组[(58.94±7.83)和(35.07±3.88)](P<0.01),血CD8+水平为(23.05±4.22),明显低于对照组[(31.43±3.57)](P<0.01),p27蛋白阳性率(75.47%)明显高于对照组(54.72%)(P=0.02)。结论:左旋甲状腺素片能降低老年甲状腺癌患者血清s IL-2R、CD44V6、TSGF表达水平,抑制p27蛋白表达,同时能明显改善患者免疫功能,值得在临床推广。Objective： To study the clinical effect of levothyroxine on the expression of p27 protein of elderly patients with thyroid cancer. Methods： 106 elderly patients with thyroid cancer in our hospital from Jun. 2014 to Jun. 2017 were divided into control group and observation group by simple random grouping method,53 cases in each group. The control group was given hormone replacement therapy,the observation group was given levothyroxine treatment,both groups were treated for 1 month. The changes of serum s IL-2 R,CD44 V6,TSGF levels,T lymphocyte subsets levels and p27 expression in the thyroid cancer tissues before and after treatment were compared between two groups. Results： After treatment,the serum levels of s IL-2 R,CD44 V6 and TSGF in the observation group were（ 378.65±30.14） μ/m L,（ 310.84±21.78） ng/m L,（ 58.86±6.78） μ/m L,which were significantly lower than those of the control group [（ 436.90±33.72） μ/m L,（ 382.43±26.06） ng/m L,（ 62.73±7.40） μ/m L]（ P〈0. 01）. The serum levels of CD3 ＋ and CD4 ＋ in the observation group were（ 67.02±8.31） and（ 27.56±4.27）,which were significantly higher than those of the control group[（ 58.94±7.83） and（ 35.07±3.88） ]（ P〈0. 01）. The serum CD8＋ level of observation group was（ 23.05±4.22）,which was significantly lower than that of the control group（ 31.43±3.57）（ P〈0.01）; the positive rate of p27（ 75.47%） expression in observation group was significantly higher than that of the control group（ 54.72%）（ P = 0. 02）. Conclusion： The levothyroxine tablet can decrease the expression of serum s IL-2 Rn CD44 V6 TSGF and inhibit the expression of p27 protein in the serum of the elderly patients with thyroid carcinoma,and it can obviously improve the immune function of the patients,which is worth popularizing in clinic.

关 键 词：左旋甲状腺素片 甲状腺癌 免疫功能 P27蛋白 

分 类 号：R736.1[医药卫生—肿瘤]