规律抗癫痫治疗对癫痫患者外周血T淋巴细胞水平变化的影响及意义  

Effect and Significance of Regular Antiepileptic Therapy on the Level of T Lymphocyte in Peripheral Blood of Epileptic Patients

作　　者：史向松 张福池 王晓华[1] 王守勇[1] SHI Xiangsong;ZHANG Fuchi;WANG Xiaohua(The Third People＇s Hospital of Huai＇an,Jiangsu Huaian 223001,China)

机构地区：[1]江苏省淮安市第三人民医院神经内科,江苏淮安223001

出　　处：《河北医学》2018年第9期1440-1443,共4页Hebei Medicine

基　　金：江苏省淮安市科技项目;(编号:HAS201613)

摘　　要：目的:探讨规律抗癫痫治疗对癫痫患者外周血T淋巴细胞水平变化的影响及临床意义。方法:在2014年1月至2017年12月期间我院收治的癫痫患者中,选择90例符合研究纳入标准及排除标准的癫痫患者进行回顾性研究,根据患者近3个月是否规律服用抗癫痫药物,将其分为规律服药组、未服药组,并选取同期在我院门诊接受健康体检的50例健康志愿者作为对照组。采集受检者外周静脉血,采用流式细胞仪对其CD3+、CD4+、CD8+等外周血T淋巴细胞水平进行测定,计算CD4+/CD8+比值,再采用免疫透射比浊法对Ig G、Ig A等免疫球蛋白水平进行检测。比较三组的外周血T淋巴细胞水平、免疫球蛋白水平。结果:规律服药组、未服药组患者的外周血CD8+明显高于对照组(P<0.05),其CD3+、CD4+、CD4+/CD8+均低于对照组(P<0.05),而规律服药组的外周血CD8+低于未服药组(P<0.05),其CD3+、CD4+、CD4+/CD8+均高于未服药组(P<0.05)。规律服药组、未服药组患者的Ig G、Ig A均低于对照组(P<0.05),而规律服药组的Ig G、Ig A均高于未服药组(P<0.05)。结论:癫痫患者普遍存在外周血T淋巴细胞和体液免疫功能紊乱状况,而经规律服用抗癫痫药物治疗可有效纠正癫痫患者的免疫功能紊乱。Objective： To explore the effect and its clinical significance of regular antiepileptic therapy on the level of T lymphocyte in peripheral blood of epileptic patients. Methods： Among the epileptic patients who were admitted to our hospital during the period of Jan. 2014 to Dec. 2017,90 cases of epilepsy patients in our hospital were selected for retrospective study,a total of 90 epileptic patients who met the inclusion criteria and exclusion criteria were selected for retrospective study,according to whether the patients took regular antiepileptic drugs in the past 3 months,they were divided into regular medication group and untreated group,and 50 healthy volunteers were selected as the control group in the outpatient department of our hospital during the same period. Peripheral venous blood was collected from the subjects,the peripheral blood T lymphocyte levels of CD3＋,CD4＋ and CD8＋ were measured by flow cytometry,the ratio of CD4＋/CD8＋ was calculated,and the immunoglobulin levels,such as Ig G and Ig A,were detected by immunoturbidimetry. The levels of T lymphocyte and immunoglobulin in peripheral blood of three groups were compared. Results： The peripheral blood of patients in regular medication group and untreated group with CD8＋ was significantly higher than the control group（ P〈0.05）,CD3＋,CD4＋,CD4＋/CD8＋ were lower than the control group（ P〈0.05）,and peripheral blood of CD8＋ in regular medication group was lower than that of untreated group（ P〈0.05）,CD3＋,CD4＋ and CD4＋/CD8＋ were higher than untreated group（ P〈0.05）. Ig G and Ig A in the regular medication group and untreated group were lower than those in the control group（ P〈0.05）,while the Ig G and Ig A in the regular medication group were higher than those in untreated group（ P〈0.05）. Conclusion： The disorder of T lymphocyte and humoral immune function in peripheral blood is common in epileptic patients,while regular use of antiepileptic drugs can effectively correct the disorder of

关 键 词：癫痫 抗癫痫药物 外周血T淋巴细胞 

分 类 号：R742.1[医药卫生—神经病学与精神病学]