氧气作为唯一氧化剂的钯催化咖啡因或尿嘧啶C—H键直接芳基化反应  

Palladium-Catalyzed C—H Direct Arylation of Uracils and Caffeines with Arenes Using Molecular Oxygen as the Sole Oxidant

作　　者：潘帼帅 吴孔川 邓泽颖 张馨予 张晓凤[1] 林深[1] 黄秋锋[1,2] Pan Guoshuai;Wu Kongchuan;Deng Zeyinga;Zhang Xinyua;Zhang Xiaofeng;Lin Shena;Huang Qiufeng(College of Chemistry ＆ Materials＇ Science,Fujian Normal University,Fuzhou 350007;Key Laboratory of Polymer Materials＇ of Fujian Provinee,Fuzhou 350007)

机构地区：[1]福建师范大学化学与材料学院,福州350007 [2]福建省高分子材料重点实验室,福州350007

出　　处：《有机化学》2018年第8期2076-2084,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.6152010615);福建省自然科学基金(No.2017J01572);福建省教育厅青年重点基金(No.JZ160424);福建省高校新世纪人才基金;福建师范大学省级大学生创新训练计划(No.201710394061)资助项目~~

摘　　要：报道了钯催化咖啡因或尿嘧啶C—H与芳烃C—H的脱氢偶联反应.反应最大特点是采用常压氧气作为唯一氧化剂.反应对很多官能团,比如卤素、酯基、硝基、腈基、醚等,都有很好的容忍度.本方法为制备C6-芳基尿嘧啶或C8-芳基咖啡因衍生物提供了简便、直接和绿色经济路线.Palladium-catalyzed cross-dehydrogenative coupling of uracil or caffeine with unactivated arenes has been devel- oped. The approach was characterized by using atmospheric pressure of molecular oxygen as the sole oxidant. Functional groups such as halo, ester, nitro, nitrile and ether are well-tolerated under the reaction conditions. This novel strategy provides a straightforward, facile and economical route to C6-aryl uracil derivatives or CS-arvl caffeine derivatives.

关 键 词：钯 咖啡因 尿嘧啶 C—H键 芳基化 氧气 

分 类 号：O621.251[理学—有机化学]