离子液体水溶液中2-甲基氮杂芳烃苄位C(sp^3)—H官能化反应  

Benzylic C(sp^3)—H Functionalization Reaction of 2-Methylazaarenes in Ionic Liquid Aqueous Solution

作　　者：艾锋[1] 谢宗波[1] 姜国芳[1] 季久健 乐长高[1] Ai Feng;Xie Zongbo;Jiang Guofang;Ji Jiujian;Le Zhanggao(Department of Applied Chemistry,East China University of Technology,Nanchang 330013)

机构地区：[1]东华理工大学应用化学系,南昌330013

出　　处：《有机化学》2018年第8期2174-2181,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21462001;21262002;21465002);江西省科技计划项目(No.20161BCB24006);江西省教育厅科技(Nos.KJLD14050;GJJ150584)资助项目~~

摘　　要：以中性离子液体水溶液为反应介质,无需催化剂的条件下,通过2-甲基氮杂芳烃苄位C(sp^3)—H与缺电子烯烃之间的加成反应,以良好产率合成了一系列氮杂芳烃衍生物.该方法操作简单,条件温和,不仅拓展了离子液体在氮杂芳烃的C(sp^3)—H官能化反应中的应用,对绿色化学的发展也有积极的推动作用.The catalyst-free addition of 2-methylazaarenes benzylic C（sp3）—H to electron-deficient olefins in neutral ionic liquid aqueous solution was reported, and a series of azaarene derivatives were obtained in good yields. This method is easy to operate and the reaction conditions are mild, which not only expands the application of ionic liquid in C（sp3）—H functionalization reaction, but also has positive significance for promoting the development of the green chemistry.

关 键 词：离子液体水溶液 缺电子烯烃 苄位C(sp^3)—H官能化 2-甲基氮杂芳烃 

分 类 号：O621.25[理学—有机化学]