癌症患者淋巴细胞亚群检测的临床意义  

Clinical Significance of Lymphocyte Subset Test of Cancer Patients

作　　者：龚莉[1] 许觉彬[1] GONG Li;XU Jue-bin(Department of Clinical Laboratory,Qidong People＇s Hospital,Qidong,Jiangsu Province,226200 China)

机构地区：[1]启东市人民医院检验科,江苏启东226200

出　　处：《系统医学》2018年第14期124-125,132,共3页Systems Medicine

摘　　要：目的对癌症患者淋巴细胞亚群检测的临床意义进行研究。方法选取该院2017年9月—2018年3月收治的86例癌症患者作为为观察组,采用流式细胞术进行患者外周血T淋巴细胞亚群水平检测,同时选取40例同期在该院接受健康检查的正常人员作为对照组,对两组人员的外周血T淋巴细胞亚群水平检测结果进行对比分析。结果与对照组相比,观察组患者外周血T淋巴细胞亚群检测中,CD3+为(46.23±12.47)、CD4+为(22.43±9.44)、CD4+/CD8+为(1.04±0.53),对照组CD3+为(69.76±5.48)、CD4+为(36.12±4.89)、CD4+/CD8+为(1.33±0.51),观察组均明显低于对照组,差异有统计学意义(t=11.287,t=6.249,t=2.876,P<0.05);两组人员CD8+水平以及癌症患者外周血T淋巴细胞亚群检测结果与其性别、年龄、癌症类型等因素差异无统计学意义(P>0.05)。结论癌症患者细胞免疫紊乱导致其外周血T淋巴细胞亚群检测多项指标水平降低,在患者病症诊断及细胞免疫功能评估中具有显著的价值和意义。Objective To research the clinical significance of lymphocyte subset test of cancer patients.Methods 86 cases of cancer patients admitted and treated in our hospital from September 2017 to March 2018 were selected as the observation group,and the level of T lymphocyte subsets in peripheral blood of patients was tested by the flow cytometry,at the same time,40 cases of normal staff for healthy physical examination in our hospital were selected as the control group,and the test results of T lymphocyte subsets in peripheral blood were compared and analyzed.Results The CD3＋,CD4＋,CD4＋/CD8＋ in the observation group were obviously lower than those in the control group,[（46.23±12.47）,（22.43±9.44）,（1.04±0.53） vs（69.76±5.48）,（36.12±4.89）,（1.33±0.51）],and the differences were statistically significant（t=11.287,t=6.249,t=2.876,P〈0.05）,and the differences in the CD8＋ level and lymphocyte subset test results of cancer patients among patients of different genders,ages and cancer types（P〉0.05）.Conclusion The levels of multiple indicators of peripheral blood T lymphocyte subsets caused by the cellular immune disorder of cancer patients decrease,which is of obvious value and significance to diagnosis of diseases and evaluation of cell immune function.

关 键 词：癌症患者 淋巴细胞亚群 检测 临床意义 

分 类 号：R733[医药卫生—肿瘤]