特异性核基质结合区结合蛋白-1、细胞核增殖抗原基因在膀胱移行细胞癌组织的表达及其临床意义  

Expression of special AT rich sequence binding protein - 1 and proliferation cell nuclear antigen gene in transitional cell carcinomas of bladder and clinical significances

作　　者：郭志成 刘渠贺 李望[1] 温儒民[1] 陈家存[1] Guo Zhicheng;Liu Quhe;Li Wang;Wen Rumin;Chen Jiacun(Department of Urology,the Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China)

机构地区：[1]徐州医学院附属医院泌尿外科,江苏221002

出　　处：《中华实验外科杂志》2018年第9期1598-1600,共3页Chinese Journal of Experimental Surgery

基　　金：江苏省自然科学基金（BK20151166）;江苏省青年医学重点人才项目（QNRC2016794）;江苏省研究生科研创新计划项目（KYCX17_1720）

摘　　要：目的探讨特异性核基质结合区结合蛋白-1（SATBl）、细胞核增殖抗原（Ki-67）在膀胱移行细胞癌（BTCC）表达及临床意义。方法应用免疫组织化学技术检测60例膀胱癌和30例正常膀胱组织中SATBl、Ki-67基因的表达，分析SATBl和Ki-67基因之间及与病理分级、临床分期之间的相关性。结果60例膀胱癌组织SATBl阳性表达率85．0％（51／60），而30例膀胱正常组织中无阳性表达，差异有统计学意义（P=0．000）；膀胱癌组织中Ki-67阳性表达率为80．0％（48／60），膀胱正常组织中无阳性表达，差异有统计学意义（P=0．000）；SATBl和Ki-67在膀胱癌组织中的表达强度与膀胱癌的病理分级（P=0．001、0．002）、临床分期（P=0．003、0．007）以及淋巴结转移（P=0．001、0．002）呈正相关，同时膀胱癌中SATBl与鼬．67表达呈正相关（r=0．601，P=0．002）。结论SATBl、Ki-67基因的表达与膀胱癌的发生和进展有关，联合检测SATBl、Ki-67基因有助于评价膀胱癌的进展和预后。Objective To investigate the significance of the expression of special AT rich se- quence binding protein - 1 （ SATB1 ） and proliferation cell nuclear antigen （ Ki - 67 ） gene in transitional cell carcinoma of bladder （BTCC）. Methods The expression of SATB1 and Ki - 67 was detected by im- munohistochemistry in 60 cases of bladder carcinoma tissues and 30 cases of normal bladder tissues respec- tively. Then their relationship with pathological grade, clinical stage were analyzed. The correlation be- tween SATB1 and Ki - 67 was also evaluated. Results The positive rate of SATB1 protein in bladder car- cinoma was 85.0% （51/60）, significantly higher than that in the normal bladder tissues （ P = 0. 000）. The positive rate of Ki -67 protein in human bladder carcinoma was 80. 0% （48/60）, obviously higher than that in the normal bladder tissue （ P = 0. 000）. The amounts of SATB1 and Ki - 67 were positively correlated with the pathological grades （P = 0. 001,0. 002）, clinical stages （P = 0. 003, 0. 007）and lym- phatic metastasis （ P = 0. 001, 0. 002 ） of BTCC. There was positive correlation between SATB1 and Ki - 67 gene expression in bladder carcinoma tissue （ r = 0. 601, P = 0. 002）. Conclusion Positive ex- pression of SATB1 and Ki -67 gene may play an important role in the development of BTCC. SATB1 and Ki - 67 gene may serve as an important molecular biological indicator in diagnosing and predicating the bio- logical behaviors of BTCC.

关 键 词：膀胱癌 特异性核基质结合区结合蛋白-1 细胞核增殖抗原 

分 类 号：R737.14[医药卫生—肿瘤]