侵袭性甲状腺乳头状微小癌的分子特征  

The molecular features of aggressive papillary thyroid microcarcinoma

作　　者：宋建鲁 杨治力[1] Song Jianlu;Yang Zhili(Department of General Surgery,Shanghai Jiao Tong University Affiliated Sixth People＇s Hospital,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院普通外科,200233

出　　处：《中华内分泌外科杂志》2018年第4期339-341,共3页Chinese Journal of Endocrine Surgery

基　　金：国家自然科学基金（81472499）

摘　　要：近年来，甲状腺乳头状微小癌（papillary thyroid microcarcinoma，PTMC）的发病率明显升高，而死亡率变化却不明显，造成了临床处理的迷惑与困境。多数学者认为，侵袭性PTMC需立即手术治疗，但尚无准确的临床病理学特征预测或评估PTMC的侵袭性。本文就侵袭性PTMC的分子遗传特征，从基因突变、微小RNA（microRNA，miRNA）、单基因表达3个层面进行综述。In recent years, the incidence of papillary thyroid microcarcinoma （PTMC） increased significantly and the mortality did not change obviously, resulting in the confusion and dilemma of clinical treatment. The majority of scholars believe that aggressive PTMC requires immediate surgical intervention, but there are no accurate clinical or pathologic features to predict or assess the aggressiveness of PTMC. In this review, the molec ular genetic characteristics of aggressive PTMC are summarized from three aspects： gene mutation, microRNA and single gene expression.

关 键 词：甲状腺乳头状微小癌 侵袭性 分子特征 

分 类 号：R736.1[医药卫生—肿瘤]