BCL11B基因在血液系统恶性肿瘤中的研究进展  

Research progress of BCL11B gene in hematological malignancies

作　　者：刘银 王亚妹 李冬娜[1] 任立成[1] LIU Yin;WANG Ya-mei;LI Dong-na;REN Li-cheng(Department of Biology,Hainan Medical University,Haikou 571199,Hainan,CHINA)

机构地区：[1]海南医学院生物学教研室,海南海口571199

出　　处：《海南医学》2018年第17期2459-2463,共5页Hainan Medical Journal

基　　金：国家自然科学基金(编号:31260269;31660318);海南省级大学生创新课题(编号:20150082)

摘　　要：BCL11基因是BCL家族的重要组成部分,与血液肿瘤的发生相关,而BCL11B基因是BCL11家族一个不可忽视的成员之一。BCL11B基因是一种重要的转录调控因子,同时也是一种肿瘤抑制基因。BCL11B基因不仅参与胸腺发生、T细胞增殖和分化等生物过程,同时也调控着淋巴造血系统的发育和增殖等。此外,BCL11B基因基因突变或者异常表达等还会导致白血病/淋巴瘤以及其他恶性肿瘤的发生。因此研究BCL11B基因能为肿瘤的发生及治疗提供理论依据。The BCL11 gene is an important component of the BCL family and is associated with the development of hematological tumors, and the BCL11 B gene is one of the most important members of the BCL11 family.BCL11 B gene is an important transcriptional regulator and a tumor suppressor gene. BCL11 B gene is involved not only in biological processes such as thymusogenesis, T cell proliferation and differentiation, but also in the development and proliferation of the lymphatic hematopoietic system. In addition, mutations or abnormal expression of the BCL11 B gene may lead to the development of leukemia/lymphoma and other malignant tumors. Therefore, the study of BCL11 B gene can provide a theoretical basis for the occurrence and treatment of tumors.

关 键 词：BCL11B 白血病 淋巴瘤 肿瘤 

分 类 号：R733[医药卫生—肿瘤]