TTF-1在小细胞肺癌和肺腺癌中的表达及其临床意义  

Expression and clinical significance of TTF-1 in small cell lung cancer and lung adenocarcinoma

作　　者：蒋中秀[1] 黄鲁众[1] 崔国元[1] 张晓晔[1] Jiang Zhongxiu;Huang Luzhong;Cui Guoyuan;Zhang Xiaoye(The Fourth Oncology Department in Shengjing Hospital of China Medical University,Liaoning Shenyang 110020,China.)

机构地区：[1]中国医科大学附属盛京医院第四肿瘤科,辽宁沈阳110020

出　　处：《现代肿瘤医学》2018年第20期3232-3236,共5页Journal of Modern Oncology

基　　金：辽宁省自然科学基金(编号:2014021032)

摘　　要：目的:探讨甲状腺转录因子-1(TTF-1)在小细胞肺癌(SCLC)和肺腺癌中的表达及其临床意义。方法:采用免疫组化SP法检测79例SCLC组织和270例肺腺癌组织中TTF-1的表达情况,统计患者的临床资料,分析TTF-1表达与临床特征的相关性,采用Kaplan-Meier曲线对随访数据进行预后分析。结果:SCLC(P<0.001)和肺腺癌(P<0.001)组织中TTF-1的表达率均显著高于癌旁肺组织,SCLC组织中TTF-1的阳性表达率明显高于肺腺癌组织(P=0.007)。SCLC组织中TTF-1的阳性表达水平与术前血清神经元特异性烯醇化酶(NSE)水平呈正相关(P=0.007),TTF-1表达阴性的患者,中位生存期明显短于表达阳性的患者(19.639个月vs 38.754个月,P=0.043)。肺腺癌组织中TTF-1的阳性表达水平与区域淋巴结转移程度(P=0.046)、术前血清癌胚抗原(CEA)水平(P=0.016)呈正相关,TTF-1的表达水平与中位生存期无关(P=0.167)。SCLC预后独立危险因素有术前血清NSE升高和TTF-1阴性表达;肺腺癌预后独立危险因素是区域淋巴结转移。结论:TTF-1可作为SCLC和肺腺癌鉴别诊断的分子标志物,可能对SCLC患者的预后有一定的指导意义。Objective ： To investigate the expression and significance of thyroid transcription factor-1 in small cell lung cancer and lung adenocarcinoma. Methods ： SP immunohistochenfistry was used to detect the expression of TTF-1 in 79 small cell lung cancer tissues and 270 lung adenocarcinoma tissues. The clinical data were collected to analyze the relationship between the expression and clinical characteristics. Kaplan-Meier curves were used to conduct sur-vival analysis of follow-up data. Results ：The expression of TTF-1 in small cell lung cancer（ P 〈 0.001 ） and lung adenocarcinoma（ P 〈 0.001 ） were both significantly higher than those of para-carcinoma lung tissues. The expres-sion of TTF-1 in small cell lung cancer was significantly higher than those of lung adenocarcinoma （ P = 0. 007 ）. There was positive correlation between the expression of TTF-1 and NSE level before surgery in small cell lung canc-er（ P = 0.007 ）. The median survival time of patients with negative expression of TTF-1 was significantly shorter than that of patients with positive expression in small cell lung cancer（ 19. 639 months vs 38. 754 months, P = 0. 043）. There was positive correlation between the expression of TTF-1 and degree of regional lymph node metastasis （P = 0.046 ） and CEA level before surgery（ P = 0. 016 ） in lung adenocarcinoma. There was no correlation between the expression of TTF-1 and the median survival time in lung adenocarcinoma（ P = 0. 167）. The independent risk factors on prognosis in small cell lung cancer were raised NSE level before surgery and negative expression of TTF-1, and the independent risk factor on prognosis in lung adenocarcinoma was regional lymph node metastasis. Conclusion： TTF-1 can be used as a molecular marker for differential diagnosis of small cell lung cancer and lung adenocarcino-ma, and may be helpful for the prognosis of patients with small cell lung cancer.

关 键 词：甲状腺转录因子-1 小细胞肺癌 肺腺癌 预后分析 

分 类 号：R734.2[医药卫生—肿瘤]