MTHFR基因C667T位点多态性与亚洲人群乳腺癌易感性的Meta分析  

Association between MTHFR C667T polymorphism and the susceptibility of breast cancer in Asian population:A Meta-analysis

作　　者：张之涛 杨仲俊 王晓琼 闫鹏 Zhang Zhitao;Yang Zhongjun;Wang Xiaoqiong;Yan Peng(Department of Oncology Surgery;Galactophore Department,Zhangye People＇s Hospital Affiliated to Hexi University,Gansu Zhangye 734000,China.)

机构地区：[1]河西学院附属张掖人民医院肿瘤外科,甘肃张掖734000 [2]河西学院附属张掖人民医院乳腺科,甘肃张掖734000

出　　处：《现代肿瘤医学》2018年第20期3246-3252,共7页Journal of Modern Oncology

摘　　要：目的:采用Meta分析的方法定量评价亚甲基四氢叶酸还原酶(MTHFR)基因C667T位点的多态性与亚洲人群乳腺癌易感性的关系。方法:计算机检索Pub Med、Web of Science、中国生物医学文献数据库、CNKI、重庆维普和万方数据库,搜索有关MTHFR基因C667T位点的多态性与亚洲人群乳腺癌易感性的研究,检索时间截止2017年2月。采用Stata 12.0软件进行统计分析。结果:共纳入24篇病例对照研究,共计7 268例乳腺癌患者,9 223例健康对照。Meta分析结果显示:MTHFR基因C667T位点的多态性均与亚洲人群乳腺癌易感性有相关性[CC vs CT:OR=0.70,95%CI(0.60,0.83),P=0.001;CT vs TT:OR=0.87,95%CI(0.79,0.96),P=0.05;CC vs TT:OR=0.79,95%CI(0.72,0.88),P=0.002;CT+TT vs CC:OR=0.81,95%CI(0.76,0.87),P=0.001;CC+CT vs TT:OR=0.85,95%CI(0.77,0.93),P=0.003]。结论:MTHFR基因C667T位点的多态性增加了亚洲人群乳腺癌的易感性。Objective ：To evaluate the association between MTHFR C667T polymorphisnl and the susceptibility-of breast cancer in Asian population. Methods： PubMed, Web of Science, Chinese Biomedical Literature Database, CNKI, Chongqing VIP and Wanfang Database were searched to identify relevant articles that investigating the associa-tion of MTHFR C667T polymorphism with breast cancer risk from their inception to February 2017. A Meta - analysis was performed using the Stata 12.0 software. Results ： A Meta-analysis of 24 ease-control studies was performed in-eluding 7 268 eases of breast cancer and 9 223 controls. The results of Meta-analysis indicated that there were signif-icant association between MTHFR C667T polymorphisnl and breast cancer susceptibility for Asian population under every genetic models [CC vs CT：OR =0.70,95% CI（0.60,0.83）,P =0.001,CT vs TT：OR =0.87,95% CI（0.79, 0.96）,P=0.05,CC vs TT：OR =0.79,95%CI（0.72,0.88）,P=0.002,CT＋TTvsCC：OR=0.81,95% CI（0.76,0.87） ,P = 0. 001, CC ＋ CT vs TT： OR = 0.85,95% CI（0. 77,0. 93 ） ,P = 0. 003] Conclusion： MTHFR C667T polymorphisnl increased the risk of breast cancer in Asian population.

关 键 词：乳腺癌 亚甲基四氢叶酸还原酶 基因多态性 META分析 

分 类 号：R737.9[医药卫生—肿瘤]