胃肠间质瘤的基因分型及相关研究进展  

The genotyping of gastrointestinal stromal tumors and related research progresses

作　　者：谢伟 王阁 Xie Wei;Wang Ge(Cancer Center,Daping Hospital,Array Medical University,Chongqing 400042,China)

机构地区：[1]陆军军医大学大坪医院肿瘤中心,重庆400042

出　　处：《现代肿瘤医学》2018年第19期3154-3158,共5页Journal of Modern Oncology

摘　　要：胃肠间质瘤(gastrointestinal stromal tumors,GISTs)是最常见的胃肠道间质肿瘤,常规化疗无效,主要的治疗方式是手术切除和靶向治疗。分子检测作为推荐的诊断标准化流程,还可以预示疾病的临床表现、治疗、预后甚至发生附加肿瘤的风险。本文对其基因型分型以及相关研究进展进行综述。Gastrointestinal stromal tumors （GISTs） are the most comnlon mesenchynlal tumor of the gastrointestinal tract. Chemotherapy is invalid and the gold standard for treating a localized primary GIST is surgical resection and targeted therapy. As the standard procedure of diagnosis, molecular detection also play a regulatory role in predicting clinical manifestation, treatment, prognosis and risk of gaining other tumors. The focus of this review is on genotyping and related research progresses.

关 键 词：胃肠间质瘤 基因型 酪氨酸激酶抑制剂 琥珀酸脱氢酶 靶向治疗 胰岛素样生长因子 野生型 

分 类 号：R730.262[医药卫生—肿瘤]