CT导向下碘-125粒子植入结合外放疗治疗肝门区肝癌的效果  

Effect of CT guided ^(125)I particle implantation combined with external radiotherapy for hepatocellular carcinoma in hilar region

作　　者：李明尧[1] 林华明[1] 麦大海[1] LI Mingyao;LIN Huaming;MAI Dahai(Department of Oncology,People＇s Hospital of Maoming City,Guangdong Province,Maoming 525000,China)

机构地区：[1]广东省茂名市人民医院肿瘤一科,广东茂名525000

出　　处：《中国医药科学》2018年第16期180-183,共4页China Medicine And Pharmacy

摘　　要：目的观察CT导向下碘-125粒子植入结合外放疗治疗肝门区肝癌临床效果。方法选取我院收治的30例肝门区肝癌患者作为研究对象,随机分为两组,A组患者(n=15)采用碘-125粒子植入结合外放疗进行治疗,B组患者(n=15)采用单纯外放疗进行治疗。观察两组患者短期治疗效果、AST、ALT、TBIL、AFP指标及远期生存率。结果 A组患者缓解率高于B组患者,差异具有统计学意义(P <0.05)。两组患者治疗后,AFP均较治疗前有所下降,但A组患者更明显,差异具有统计学意义(P <0.05)。A组患者中位生存期为26.0(95%CI:18.4~33.6)个月,B组患者中位生存期为17.0(95%CI:15.3~18.6)个月,两组患者生存率比较,差异具有统计学意义(P <0.05)。结论 CT导向下碘-125粒子植入结合外放疗治疗肝门区肝癌不仅可以有效提高患者短期治疗效果,而且能够降低患者AFP,同时未引起AST、ALT、TBIL明显改变,并且能够延长肝门区肝癌患者的生存期。Objective To observe the clinical effect of CT guided 125I particle implantation combined with external radiotherapy in the treatment of hilar carcinoma. Methods Thirty patients with hilar carcinoma who were treated in our hospital were selected and randomly divided into two groups. Patients in group A （n=15） were treated with CT guided 125I particle implantation combined with external radiotherapy. Patients in group B （n=15） were treated with external radiotherapy. Short-term treatment effect, AST, ALT, TBIL, AFP and long-term survival were observed in the two groups. Results The remission rate of patients in group A was higher than that in group B, the difference was statistically significant （ P 〈 0.05）. After treatment, AFP in both groups was lower than that before treatment, the patients in group A were more obvious, and the difference was statistically significant （ P 〈 0.05）. The median survival time was 26.0 （95%CI： 18.4-33.6） months in group A and 17.0 （95%CI： 15.3-18.6） months in group B. The difference in survival rate between the two groups was statistically significant （ P 〈 0.05）. Conclusion CT guided 125I particle implantation combined with external radiotherapy in the treatment of hilar carcinoma can not only effectively improve the short-term treatment effect, but also reduce AFP, at the same time, AST, ALT and TBIL are not changed significantly, and the survival time of patients with hilar carcinoma is prolonged.

关 键 词：碘-125 CT导向 外放疗治 肝门区肝癌 

分 类 号：R735.7[医药卫生—肿瘤]