侵袭性骨肿瘤组织中P53、P21、Bcl-2的表达  

Expressions of P53,P21 and B-cell Lymphoma/Leukemia-2 in the Invasive Bone Tumor

作　　者：董孝龙 DONG Xiaolong(Department of Orthopaedics,Shangqiu Fourth People＇s Hospital,Shangqiu 476005,China)

机构地区：[1]商丘市第四人民医院骨科,河南商丘476005

出　　处：《肿瘤基础与临床》2018年第4期290-292,共3页journal of basic and clinical oncology

基　　金：国家博士后基金面上项目(编号:2014M562001)

摘　　要：目的探讨侵袭性骨肿瘤组织中P53、P21、B细胞淋巴瘤/白血病-2(Bcl-2)的表达及其意义。方法应用免疫组化和凋亡试剂盒检测62例侵袭性骨肿瘤组织中P53、P21、Bcl-2的表达和细胞凋亡情况。结果良性骨肿瘤细胞凋亡率为76. 31%,高于恶性骨肿瘤的53. 28%(P <0. 05)。良性骨肿瘤组织中P53、P21、Bcl-2阳性表达表达率分别为66. 51%、45. 58%、0. 00%,低于恶性骨肿瘤的79. 54%、72. 89%、22. 56%(P均<0. 05)。COX比例风险模型分析显示恶性骨肿瘤组织中P53、P21和Bcl-2蛋白表达与年龄、类型、病程、侵袭程度有关(P均<0. 05)。结论 P53、P21、Bcl-2在侵袭性骨肿瘤组织中异常表达,并在骨肿瘤的发生、发展中可能起重要作用。Objective To explore the expression and significance of P53, P21 and B-cell lymphonla/leukenlia-2 （ Bcl-2 ） in the invasive bone tumor. Methods Immunohistochenlistry and apoptosis assay were used to detect the expressions of P53, P21, Bcl-2 and the apoptosis in the bone tumor. Results The apoptosis rate （76.31%） of the benign bone tumor was higher than that of the malignant bone tumor （53.28 % , P 〈 0.05）. The positive expression rates of P53, P21 and Bcl-2 of the benign bone tumor （66.51% , 45.58% and 0.00% ） were lower than those of the malignant bone tumor （79.54% , 72.89% and 22.56% ; P 〈 0.05）. COX proportional risk model analysis showed that the expressions of P53, P21 and Bel-2 protein in the malignant bone tumor were related to age, type, course and invasion degree （P 〈 0.05）. Conclusion The expressions of P53, P21 and Bcl-2 are abnormal in the invasive bone tumors, and may play an important role in the occurrence and development of bone tumors.

关 键 词：侵袭性骨肿瘤 细胞凋亡 P53 P21 B细胞淋巴瘤/白血病-2 

分 类 号：R738.1[医药卫生—肿瘤] R730.4[医药卫生—临床医学]