异柠檬酸脱氢酶1在大脑胶质瘤组织中表达的意义  

Expression of Isocitrate Dehydrogenase 1 in the Brain Glioma

作　　者：刘晋发 朱文标[1] 谢寿城[1] 陈纪欢[2] 郭维新[3] LIU Jinfa;ZHU Wenbiao;XIE Shoucheng;CHEN Jihuan;GUO Weixin(Department of Pathology,Meizhou City People＇s Hospital,Meizhou 514031,China;Department of Neurosurgery,Meizhou City People＇s Hospital,Meizhou 514031,China;Department of Chemotherapy,Meizhou City People＇s Hospital,Meizhou 514031,China)

机构地区：[1]梅州市人民医院病理科,广东梅州514031 [2]梅州市人民医院神经外科,广东梅州514031 [3]梅州市人民医院化疗科,广东梅州514031

出　　处：《肿瘤基础与临床》2018年第4期295-297,共3页journal of basic and clinical oncology

基　　金：梅州市社会发展科技计划项目(编号:2017B015)

摘　　要：目的探究异柠檬酸脱氢酶1(IDH1)在大脑胶质瘤中表达的临床意义。方法采用免疫组化法检测30例大脑胶质瘤组织(Ⅰ～Ⅱ级胶质瘤11例、Ⅲ～Ⅳ级胶质瘤19例)和30例正常脑组织中IDH1的表达。结果Ⅰ～Ⅱ级胶质瘤组织、Ⅲ～Ⅳ级胶质瘤组织中IDH1表达高于正常脑组织,Ⅲ～Ⅳ级胶质瘤组织中IDH1表达高于Ⅰ～Ⅱ级胶质瘤组织,差异均有统计学意义(P均<0. 05)。结论脑胶质瘤组织中IDH1水平明显增高,提示其可能参与了脑胶质瘤的发生、发展过程。Objective To explore the expression and clinical significance of isocitrate dehydrogenase 1 （IDH1） in the brain glioma. Methods hnmunohistochenlical method was used to detect the IDH1 expression in the 30 cases of brain glioma tissues （11 cases of Ⅰ -Ⅱ grade glioma and 19 cases of Ⅲ～Ⅳ grade glioma） and the 30 cases of normal brain tissues. Results Compared with the normal brain, the IDH1 expression in the grade Ⅰ -Ⅱ glioma and the Ⅲ～Ⅳ glioma were higher（P 〈0.05）. Compared with the grade Ⅰ -Ⅱ glioma, the IDH1 expression in the Ⅲ～Ⅳ glioma were higher（ P 〈 0.05 ）. Conclusion In the brain glioma, higher IDH1 expression are observed, and the high expression of IDH1 can improve the occurrence and development of brain glioma.

关 键 词：脑胶质瘤 免疫组织化学 异柠檬酸脱氢酶1 

分 类 号：R739.41[医药卫生—肿瘤] R730.23[医药卫生—临床医学]