啤酒抗冷混浊硅基吸附剂对SD大鼠的胚胎毒性和致畸毒性  

Teratogenic investigation of a silicon adsorbent for cold turbidity of beer on SD rats

作　　者：赵康涛[1] 王清洪 林健[1] ZHAO Kangtao;WANG Qinghong;LIN Jian(Fujian Center for Disease Control and Prevention/Fujian Provincial Key Laboratory Zoonosis Research,Fuzhou 350001;Fujian University of Traditional Chinese Medicine,Fuzhou 350001,Fujian,China)

机构地区：[1]福建省疾病预防控制中心/福建省人兽共患病研究重点实验室,福建福州350001 [2]福建中医药大学,福建福州350001

出　　处：《癌变．畸变．突变》2018年第5期400-402,406,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的:检测啤酒抗冷混浊硅基吸附剂对大鼠的胚胎毒性及致畸毒性。方法:按0.83、1.67、3.33g/kg灌胃给予孕期第7～16天的SD大鼠啤酒抗冷混浊硅基吸附剂水溶液,每天1次,连续给予10d后检查受试物对孕鼠体质量,胚胎发育,胎仔身长、尾长、外观畸形、内脏畸形和骨骼畸形的影响。同时设阴性对照组(蒸馏水)。结果:与阴性对照组比较,啤酒抗冷混浊硅基吸附剂各剂量组孕鼠及胎鼠的各项观察指标的差异均无统计学意义(P均>0.05)。结论:啤酒抗冷混浊硅基吸附剂对SD大鼠无胚胎毒性和致畸毒性。OBJECTIVE： To investigate embryo toxicity and teratogenicity of a silicone adsorbent for cold turbidity of beer on rats. METHODS ： SD rats during pregnancy were given intragastric administration of silicon-based sorbent at 0.83, 1.67 and 3.33 g/kg, respectively. After continuous administration of 10 d, growth of pregnant rats, embryonic development, fetal appearance, visceral deformities, and skeletal deformities were monitored. RESULTS： There was no significant difference in the observation indexes between pregnant rats and fetal rats in each dose group and the negative control group （all P〉0.05）. CONCLUSION： The silicon sorbent did not show reproductive toxicity nor teratogenic effects in SD rats.

关 键 词：纳米材料 硅基吸附剂 胚胎毒性 致畸毒性 大鼠 

分 类 号：R394.6[医药卫生—医学遗传学] Q355[医药卫生—基础医学]