男性危重患者血清睾酮水平及与APACHEⅡ评分的相关性研究  

Serum total testosterone in male critically ill patients： correlations with APACHEⅡ score

作　　者：惠智艳[1] 房阁[1] 张旭 袁清霞[1] Hui Zhi-yan;Fang Ge;Zhang Xu;Yuan Qing-xia(Department of Critical Care Medicine,Yan＇an University Affiliated Hospital,Yan＇an 716000,China)

机构地区：[1]延安大学附属医院重症医学科,陕西延安716000

出　　处：《中国急救医学》2018年第9期803-806,共4页Chinese Journal of Critical Care Medicine

摘　　要：目的 探讨重症加强治疗病房（ICU）男性危重患者血清睾酮（TT）水平与急性生理学与慢性健康状况评分系统Ⅱ（APACHEⅡ）评分之间的关系。〖HTH〗方法〓〖HTSS〗选择延安大学附属医院2016-05～2018-03 ICU收治的75例男性危重患者，入ICU后24 h内进行 APACHEⅡ评分，根据分值分为两组：A组＜20分（n=25）和B组≥20分（n=50），比较TT水平；根据年龄分为两组：C组＜50岁 （n=28），D组≥50岁 （n=47），比较TT水平；并将TT水平与APACHEⅡ评分进行 Pearson 相关性分析。 结果 根据APACHEⅡ评分分组，A组TT水平［（5.39±1.83）ng/dL］明显高于B组［（2.68±2.04）ng/dL］， P＜0.01） ；根据年龄分组，两组TT水平比较，差异无统计学意义（P＞0．05）；TT水平与APACHEⅡ评分具有相关性，呈显著负相关（r=-0.70，P=0.00）。 结论 男性危重患者TT越低，病情越重，与APACHEⅡ评分之间有良好的相关性，对男性危重患者及早监测TT水平对评估病情有一定参考价值。Objective To investigate serum total testosterone（TIT） in male critically ill patients of intensive care unit （ICU） and the correlations with acute physiology and the evaluation of chronic health status assessment system （APACHE Ⅱ）. Methods The 75 male patients admitted to ICU of Yan＇an University Affiliated Hospital from May 2016 to March 2018 were enrolled. All patients were calculated APACHE Ⅱ score within the first 24 h after ICU and monitored for serum TT in second morning. They were divided into two groups according to the score ： group A 〈 20 score （ n = 25 ） and group B≥20 score（ n = 50）, and compared the levels of serum TT; According to age [ group C 〈 50 years old （ n = 28 ） , group D ≥ 50 years old （ n = 47 ） 1 were divided into two groups, and compared serum TT levels; furthermore, analyzed the correlations between serum TT and APACHEⅡ score with Pearson correlation analysis. Results According to the APACHE Ⅱ score, the serum Tr [ （ 5.39± 1.83）ng/dL] in group A was significantly higher than that in group B [ （2.68 ± 2.04）ng/dL, P 〈 0.01 ]. There was no significant difference in serum TT between two groups were divided according to age. There was a significant negative correlation between serum TF and APACHE Ⅱ score （ r = - 0.70, P =0.00）. Conclusion The lower serum TT, the more serious the disease, and there is a good correlation between the serum TT and APACHE Ⅱ score in the critically ill male patients. This implied that it was also important to monitor serum TT earlier in order to assess the severity of the diseases except the APACHE Ⅱ score in critical ill male patients.

关 键 词：危重患者 血清睾酮(TT) 急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分 

分 类 号：R576[医药卫生—消化系统]