A new cytotoxic salannin-class limonoid alkaloid from seeds of Azadirachta indica A. Juss  

作　　者：Jianxun Zhu Xiaofeng Lu Xiaona Fan Ruibo Wu Hongjuan Diao Rongmin Yu Hanhong Xu Jiachen Zi 

机构地区：[1]Biotechnological Institute of Chinese Materia Medica, Jinan University [2]College of Pharmacy, Jinan University [3]School of Life Sciences, Sun Yat-sen University [4]School of Pharmaceutical Science, Sun Yat-sen University [5]State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University

出　　处：《Chinese Chemical Letters》2018年第8期1261-1263,共3页中国化学快报（英文版）

基　　金：supported by grants from Thousand Young Talents Program of China and the National Natural Science Foundation of China (No. 81673530)

摘　　要：A new cytotoxic salannin-class limonoid alkaloid, azadiramide A（1）,was isolated from seeds of Azadirachta indica A. Juss. Its structure was elucidated by extensive analysis of spectroscopic data and quantum chemical calculation. Compound 1 is a rare salannin-class limonoid alkaloid. To our best knowledge, only two compounds belonging to this type were so far found. It showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC_（50） value of 2.70±0.63 μmol/L.A new cytotoxic salannin-class limonoid alkaloid, azadiramide A（1）,was isolated from seeds of Azadirachta indica A. Juss. Its structure was elucidated by extensive analysis of spectroscopic data and quantum chemical calculation. Compound 1 is a rare salannin-class limonoid alkaloid. To our best knowledge, only two compounds belonging to this type were so far found. It showed inhibitory activity against human breast cancer MDA-MB-231 cell line with IC_（50） value of 2.70±0.63 μmol/L.

关 键 词：Azadirachta indica LIMONOID ALKALOID Cytotoxic activity 

分 类 号：TQ464.4[化学工程—制药化工]