A five-component one-pot synthesis of phosphatidylinositol pentamannoside(PIM_5)  

作　　者：Dong Wang De-Cai Xiong Xin-Shan Ye 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University

出　　处：《Chinese Chemical Letters》2018年第9期1340-1342,共3页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.21232002,21572012,and 21772006);Beijing Natural Science Foundation(No.2142015);Beijing Higher Education Young Elite Teacher Project(No.YETP0063)

摘　　要：A practical and efficient synthesis of phosphatidylinositol pentamannoside （PIM5） was achieved based on a five-component one-pot sequential glycosylation protocol with exclusive regio- and stereo-selectivity. Two regioselective sequential glycosylations on inositol and p-tolyl thioglycosides as the sole type of building blocks made this protocol to avoid the tedious protective group manipulations. This synthetic strategy provides access to other important glycolipids with similar structures.A practical and efficient synthesis of phosphatidylinositol pentamannoside （PIM5） was achieved based on a five-component one-pot sequential glycosylation protocol with exclusive regio- and stereo-selectivity. Two regioselective sequential glycosylations on inositol and p-tolyl thioglycosides as the sole type of building blocks made this protocol to avoid the tedious protective group manipulations. This synthetic strategy provides access to other important glycolipids with similar structures.

关 键 词：Phosphatidylinositol pentamannoside GLYCOSYLATION Preactivation One-pot synthesis THIOGLYCOSIDE 

分 类 号：O629.13[理学—有机化学]