肺癌根治术中胸膜腔冲洗液肿瘤细胞检查的研究进展  

Latest Progress of Intraoperative Pleural Lavage Cytology in Lung Cancer Surgery

作　　者：陈东来[1] 付冉冉 石平凡 覃塽 陈昶[1] Donglai CHEN;Ranran FU;Pingfan SHI;Shuang QIN;Chang CHEN(Department of Thoracic Surgery,Shanghai Pulmonary Hospital,Tongji University School of Medicine,Shanghai 200433,China;Tongji University School of Medicine,Shanghai 200092,China)

机构地区：[1]同济大学附属上海市肺科医院,上海200433 [2]同济大学医学院,上海200092

出　　处：《中国肺癌杂志》2018年第9期719-726,共8页Chinese Journal of Lung Cancer

基　　金：国家自然科学基金面上项目(No.81570014);上海领军人才计划(2015057)资助~~

摘　　要：非小细胞肺癌(non-small cell lung cancer, NSCLC)根治术中胸腔冲洗液细胞学检查是一种常用的检测肿瘤进展并评估患者预后的诊断技术。长期以来大量研究者致力于阐明术中胸腔冲洗液细胞学检查结果与肺癌患者术后生存及肿瘤复发转移的关系。由于不同研究间存在明显异质性,其结论也各有不同。但能肯定的是,胸腔冲洗液肿瘤细胞检查阳性已被证实为手术患者的不良预后因素之一。本文尝试从临床意义、影响因素及可能发生机制等角度就近年来术中胸膜腔冲洗的研究进展作一综述。Intraoperative pleural lavage cytology is a diagnostic technique used to detect tumor cells and serve as a prognostic parameter for non-small cell lung cancer （NSCLC） patients. In the past several decades, many scholars have been dedicated to clarifying the relationships between positive intraoperative pleural lavage cytology results and postoperative sur- vival as well as tumor recurrence and metastasis. However, the findings remained various due to the inhomogeneity of different research. It has been confirmed that a positive intraoperative pleural lavage cytology result is one of the risk factors for the prog- nosis of postoperative patients. This study reviewed the advances in research of intraoperative pleural lavage cytology in recent years from several aspects, including clinical significance, influencing factors and possible mechanisms.

关 键 词：肺肿瘤 术中胸腔冲洗液 肿瘤细胞 预后 

分 类 号：R734.2[医药卫生—肿瘤]