缺血性肝炎的研究进展  

Research progress of ischemic hepatitis

作　　者：沈本强 董立谦 麻勇[1] Shen Benqiang;Dong Liqian;Ma Yong(Department of Hepatic Surgery,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院肝脏外科,150001

出　　处：《中华肝脏病杂志》2018年第9期707-709,共3页Chinese Journal of Hepatology

基　　金：国家自然科学基金（81470876,81270527）

摘　　要：缺血性肝炎，也称为缺氧性肝炎或休克肝，是指在没有任何已知的急性肝炎病因的情况下，肝细胞出现损伤，表现为急性、短暂的转氨酶水平升高（高于正常值的20倍）。该病的发病率为2．5％～10％，住院病死率大于50％。当前研究认为该病的危险因素较多，包括全身性低血压、低心输出量、败血症及呼吸窘迫等，但最终会表现为肝细胞功能障碍，即肝衰竭。低血压是其高死亡率主要的原因，治疗的关键是纠正血液动力学障碍问题。现就缺血性肝炎的病因、机制、临床表现等方面的研究进展作以综述。Ischemic hepatitis, also known as hypoxic hepatitis or shock liver, refers to liver cell damage without any known cause of acute hepatitis, and is characterized by transient elevation of transaminase levels （20 times higher than normal valuc）.The incidence of the disease is about 2.5% to 10%, and the hospital mortality rate is greater than 50%. Current research suggests that there are many risk factors for the disease, including systemic hypotension, low cardiac output, sepsis and respiratory distress, but eventually it will manifest as hepatocyte dysfunction. Unfortunately, the mortality rate related with hypotension is high, and the key to treatment is to correct hemodynamic disorders. This article reviews the research progress in the etiology, mechanism and clinical manifestations of ischemic hepatitis.

关 键 词：肝炎 肝衰竭 缺血 休克 

分 类 号：R575.1[医药卫生—消化系统]