咖啡酸对食管癌放疗后骨髓抑制的防治效果  

Effects of caffeic acid on radiotherapy-induced bone marrow suppression in patients with esophageal cancer

作　　者：杜遵民[1] 贾海鹏 杨莉莉[1] 陈洪雷[1] 陈方国[1] DU Zunmin;JIA Haipen;YANG Lili;CHEN Honglei;CHEN Fangguo(Department of Hematology,N0.88 Hospital of PLA,Shandong Province,Taian 271000,China;Department of Hematology,the Affiliated Hospital of Taishan Medical College,Shandong Province,Taian 271000,China)

机构地区：[1]解放军第八十八医院血液科,山东泰安271000 [2]泰山医学院附属医院血液科,山东泰安271000

出　　处：《中国医药导报》2018年第26期85-89,共5页China Medical Herald

基　　金：山东省泰安市科技发展计划项目(2015NS1128)

摘　　要：目的观察咖啡酸片防治食管癌患者放疗所致骨髓抑制的临床效果。方法选择2014年6月~2017年10月解放军第八十八医院经病理证实并接受放疗的食管癌患者72例,采用随机数字表法分为咖啡酸(CFA)组和对照组,每组各36例。CFA组从放疗开始口服咖啡酸片300 mg/次,3次/d,至放疗结束,共6周;对照组单纯放疗,不服用任何升血药物,当出现出现骨髓抑制时,再给予重组人粒细胞刺激因子注射液和/或重组人白细胞介素-11注射剂,直至血象正常。观察两组骨髓抑制发生率和白细胞、血红蛋白和血小板水平。结果 CFA组患者骨髓抑制发生率、Ⅲ度和Ⅳ度骨髓抑制发生率明显低于对照组,差异有统计学意义(P<0.05);CFA组患者放疗后1~6周各时间点白细胞和血小板数均明显高于对照组,差异有统计学性意义(P<0.05);CFA组患者放疗后2~6周各时间点血红蛋白水平明显高于对照组,差异有统计学性意义(P<0.05)。结论咖啡酸防治食管癌患者放疗所致的骨髓抑制效果显著。Objective To investigate the clinical effects of caffeic acid （CFA） on bone marrow suppression induced by radiotherapy in patients with esophageal cancer. Methods From June 2014 to October 2017, in NO.88 Hospital of PLA, 72 patients wilh esophageal cancer were selected, 1hey were divided into CFA group and control group by random number table, with 36 cases in each group. Patients in CFA group were given oral CFA tablet 300 mg/time, 3 times/d, lasted until the end of radiotherapy, for 6 weeks; patients in control group were given radiotherapy only, once the bone marrow suppression occured, according to the degree of leucopenia or thrombocytopenia, the patients were given recom- binant human granulocyte colony stimulating factor and/or recombinant human interleukin-11 injection subcutaneously. The incidence rate of bone marrow suppression, number of white blood cells （WBC）, hemoglobin （Hb）, platelet （P1T） were observed. Results The incidence rate of bone marrow suppression, incidence rate of 1]I and 1V degree bone mar- row suppression in the CFA group were significantly lower than the control group, the differences were statistically sig- nificant （P 〈 0.05）. The number of WBC and P1T in the CFA group 1-6 weeks af, er radiotherapy were significantly higher than the control group, the differences were statistically significant （P 〈 0.05）. The number of Hb in the CFA group 1-6 weeks after radiotherapy was significantly higher than the control group, the differences were statistically significant （P 〈 0.05）. Conclusion Caffeie acid can effectively prevent and treat bone marrow suppression induced by radiotherapy in patients with esophageal cancer.

关 键 词：咖啡酸 食管癌 放疗 骨髓抑制 

分 类 号：R735.1[医药卫生—肿瘤]