247例乳腺癌术后常规放疗的预后因素分析  

Prognostic factors analysis of conventional radiotherapy for postoperative breast cancer in 247 cases

作　　者：刘燚 李建军[1] Liu Yi;Li Jianjun(Department of Radiotherapy,The First Affiliated Hospital,China Medical University,Shenyang,Liaoning,110001,China)

机构地区：[1]中国医科大学附属第一医院放疗科,辽宁沈阳110001

出　　处：《当代医学》2018年第26期13-16,共4页Contemporary Medicine

摘　　要：目的探讨247例乳腺癌术后常规放疗的预后影响因素。方法回顾性研究纳入247例2008年8月~2015年1月于中国医科大学附属第一医院就诊的乳腺癌术后放疗患者。收集患者的临床资料和放疗前血常规。以中位数4.17为红细胞计数(RBC)的截点值。KaplanMeier法得出患者5年DFS和OS,Log-rank方法用于单因素分析,Cox regression模型用于多因素分析。P<0.05代表差异有统计学意义。结果 247例患者中,放疗前的RBC在乳腺癌放疗DFS的单因素(P=0.036)和多因素(P=0.036,HR:0.518,95%CI:0.280~0.958)中均具有统计学意义。组织学分级、N分期、ER、HER2在乳腺癌放疗OS的单因素和多因素(P=0.005、0.003、0.015和0.010)中差异均有统计学意义。结论放疗前RBC是乳腺癌放疗DFS的独立预后因素,组织学分级、N分期、ER和HER2是乳腺癌放疗OS的独立预后因素。Objective To investigate the prognostic factors of postoperative radiotherapy for breast cancer in 247 cases. Methods Retrospective study included 247 patients with breast cancer postoperative radiotherapy at the First Hospital of China Medical University from August 2008 to January2015. Patients clinical data and blood routines before radiotherapy were collected. The median was used to the cut-off values for red blood cell count（RBC）. Kaplan-Meier method was used to obtain 5-year DFS and OS, Log-rank method for univariate analysis and Cox regression model for multivariate analysis. P〈0.05 represents a statistically significant. Results Among the 247 patients, RBC before radiotherapy was statistically significant in univariate （P=0.036） and multivariate analysis of DFS （P=0.036, HR： 0.518, 95%CI：0.280-0.958）. Histological grade, N stage, ER state and HER2 stage were statistically significant in univariate and multivariate analysis of OS （P=0.005、0.003、0.015 and 0.010 respectively）. Conclusion PLR before radiotherapy was independent prognostic factors for DFS in breast cancer radiotherapy. Histological grade, N stage, ER state and HER2 stage were independent prognostic factors for OS in breast cancer radiotherapy.

关 键 词：红细胞计数 乳腺癌放疗 预后因素 

分 类 号：R737.9[医药卫生—肿瘤]