放疗期间及放疗后鼻腔冲洗频率对鼻咽癌患者的效果评价  

Effects of the Nasal Cavity Irrigation Frequency During and after Radiotherapy in Nasopharyngeal Carcinoma Patients

作　　者：唐忠敏[1] 陈丽君[2] 赖小英[1] 覃学燕[1] 韩忠秀[1] 何乾英[1] 梁宇晨 TANG Zhong-min;CHEN Li-jun;LAI Xiao-ying;QIN Xue-yan;HAN Zhong-xiu;HE Qian-ying;LIANG Yu-chen(Department of Radiation Oncology,Cancer Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning,Guangxi,530021,China;Department of Quality Control,Cancer Hospital of Guangxi Medical University,Guangxi Zhuang Autonomous Region,Nanning,Guangxi,530021,China)

机构地区：[1]广西医科大学附属肿瘤医院放疗一病区,广西南宁530021 [2]广西医科大学附属肿瘤医院质控科,广西南宁530021

出　　处：《蛇志》2018年第3期495-497,共3页Journal of Snake

基　　金：广西医药卫生科研课题(Z2012340)

摘　　要：目的探讨放疗期间及放疗后鼻腔冲洗频率对鼻咽癌患者的效果评价。方法选取120例患者随机分为A、B、C 3组。A组放疗至40Gy时开始鼻腔冲洗,每天1次至放疗结束;B组自放疗开始即行鼻腔冲洗,每天1次至放疗结束后1年;C组自放疗开始每天1次鼻腔冲洗,放疗至40Gy时冲洗频率改为每天2次至放疗结束,再持续每天鼻腔冲洗1~2次至放疗结束后1年,分别于放疗至40Gy时、放疗结束后、放疗结束后1年采用视觉模拟量表(VAS)、RTOG放射性鼻咽黏膜反应诊断标准、生命质量核心问卷(QLQ-C30)对患者鼻腔冲洗效果进行评价。结果放疗至40Gy时,3组比较仅放射性鼻腔黏膜反应差异有统计学意义;放疗结束时,VAS舒适度比较,A组与B、C组存在统计学差异;而放射性鼻腔黏膜反应比较,B组与C组存在统计学差异;放疗结束后1年,B、C两组VAS舒适度优于A组,差异有统计学意义(P<0.05)。结论鼻咽癌放疗患者应尽量于放疗开始时即持续鼻腔冲洗,随着放疗剂量的增加,可适当增加鼻腔冲洗次数,放疗结束后坚持持续冲洗。Objective Explore the effect of the nasal cavity irrigation frequency during radiotherapy and after radiotherapy in nasopharyngeal carcinoma patients. Methods Select 120 patients randomly divided into A,B,C 3 groups.Group A start nasal cavity irrigation while the radiation to 40 gy 1 time a day until the end of radiotherapy;Group B start 1 time a day from the beginning of radiotherapy to 1 year after fininishing;Group C start 1 time a day from the beginning of radiotherapy to 40 gy,then 2 times a day until the end of radiotherapy,continuous 1 time again until 1 year after fininishing,respectively at 40 gy,fininishing radiation therapy,1 year after fininishing,using visual analog scale （VAS）,diagnostic criteria of RTOG radioactive nasopharyngeal mucosa reaction,quality of life questionnaire （QLQ-C30） to evaluate the effect of patients＇ nasal cavity irrigation. Results To 40 gy,only the difference of radioactive nasal mucosa reaction was statistically significant;fininishing of radiotherapy,VAS comfort,statistical differences in group A and B,C;But in radioactive nasal mucosa reaction,group B and group C has statistical differences;1 year after fininishing,in VAS comfort,radioactive mucous membrane reaction,group B and group C are all better than group A,the difference was statistically significant（ P 〈0.05）. Conclusion Nasopharyngeal carcinoma patients suffered radiotherapy should srart nasal cavity irrigation at the beginning of radiotherapy as far as possible,with the increase of radiation dose,can increase nasal cavity irrigation＇s times appropriately,then insist on nasal cavity irrigation daily after radiotherapy.

关 键 词：鼻咽癌 鼻腔冲洗 放射治疗 

分 类 号：R739.62[医药卫生—肿瘤]