TP与PF化疗方案对宫颈癌患者近期疗效及VEGF和MVD的影响研究  

The short-term effect of TP and PF chemotherapy regimen on cervical cancer patients and the influence on VEGF and MVD

作　　者：吴华 谢旭敏[1] 金晓可[1] 张润利 WU Hua;XIE Xumin;JIN Xiaoke;Zhang Runli(Department of Obstetrics and Cynecology,Lishui Hospital of Traditional Chinese Medicine,Lishui 323000,Zhejiang,China;Linwei District Materhal and Child Health Care Family Planning Center,Weinan714000,Shaanxi,China)

机构地区：[1]丽水市中医院妇产科,浙江丽水323000 [2]渭南市临渭区妇幼保健计划生育中心妇保科,陕西渭南714000

出　　处：《中国性科学》2018年第7期36-39,共4页Chinese Journal of Human Sexuality

摘　　要：目的:分析紫杉醇与顺铂联合化疗方案(TP)与顺铂联合5-FU(PF)化疗方案对宫颈癌患者近期疗效及血管内皮生长因子(VEGF)和微血管密度(MVD)的影响。方法:选取从2015年2月至2016年3月丽水市中医院妇产科收治的84例宫颈癌患者为研究对象,按随机表法将其分为观察组与对照组,每组42例。观察组患者采用TP化疗方案;对照组患者采用PF化疗方案。比较两组患者治疗效果和不良反应发生情况,检测比较患者VEGF水平和MVD计数。结果:观察组患者治疗后VEGF阳性表达率由76.19%降至33.33%(P<0.05);两组患者治疗后VEGF水平和MVD计数明显降低,且观察组明显低于对照组(P<0.05)。观察组总有效率92.86%显,著高于对照组71.43%(P<0.05);观察组发生肝功能损伤的患者多于对照组,但肾功能损伤人数低于对照组,消化道反应显著低于对照组(P<0.05)。结论:与PF方案相比,TP化疗方案治疗宫颈癌患者近期疗效确切,且能够有效降低VEGF和MVD的水平,降低消化道不良反应发生率。Objective： To analyze the short-term effect of TP and PF chemotherapy regimen on cervical cancer patients and the influence on vascular endothelial growth factor （VEGF） and microvascular density （MVD）.Methods： 84 patients with cervical cancer from February 2015 to March 2016 were randomly divided into observation group and control group,42 cases in each group. The patients in the observation group were treated with TP chemotherapy,and patients in the control group were treated with PF chemotherapy. The treatment effect,incidence of adverse reactions,MVD count and VEGF levels were compared between the two groups. Results： In the observation group,the positive expression rate of VEGF was decreased from 76. 19% to 33. 33% （P〈 0. 05）. After treatment,MVD count and VEGF levels were significantly decreased in both groups,significantly lower in the observation group than the control group （P〈 0. 05）. The total efficiency of the observation group of 92. 86% was significantly higher than the control group of 71. 43% （P〈 0. 05）. The patients with liver function injury in observation group were more than those in control group,but the number of renal function impairment was lower than that of control group,and that with digestive tract reaction was lower than that of control group （P〈 0. 05）. Conclusions：Compared with the PF regimen,the TP chemotherapy regimen is effective in the treatment of cervical cancer,which can effectively reduce the levels of VEGF and MVD,and reduce the incidence of adverse reactions of gastrointestinal tract.

关 键 词：TP化疗方案 宫颈癌 血管内皮生长因子 微血管密度 

分 类 号：R737.33[医药卫生—肿瘤]