腹腔镜与开腹子宫肌瘤剔除术对患者性激素和生活质量的影响  

Influence of laparoscopic and laparotomy myomectomy on the sex hormones and quality of life of patients

作　　者：黄俊 魏兆莲[2] 张岩[1] 唐锦莉 HUANG Jun;WEI Zhaolian;ZHANG Yan;TANG Jinli(Department of Obstetrics and Gynecology,Ma＇ans han Central Hospital,Ma＇anshan 243000,Anhui,China;Reproductive Medicine Center,The First Hospital Affili ated to Anhui Medical University,Hefei 230022,Anhui,China;Department of Clinical Laboratory,Ma＇anshan Central Hospital,Ma＇anshan 243000,Anhui,China)

机构地区：[1]马鞍山市中心医院妇产科,安徽马鞍山243000 [2]安徽医科大学第一附属医院生殖中心,合肥230022 [3]马鞍山市中心医院检验科,安徽马鞍山243000

出　　处：《中国性科学》2018年第7期67-70,共4页Chinese Journal of Human Sexuality

基　　金：国家科技支撑计划课题项目(2012BAI32B01)

摘　　要：目的:探讨腹腔镜与开腹子宫肌瘤剔除术对患者性激素和生活质量的影响。方法:选取2015年1月至2017年6月马鞍山市中心医院收治的96例子宫肌瘤患者作为研究对象,根据治疗方案将96例患者分为腹腔镜组(60例)与开腹组(36例),腹腔镜组采取腹腔镜子宫肌瘤剔除术,开腹组采取开腹子宫肌瘤剔除术,比较两组患者的促卵泡刺激素(FSH)、雌二醇(E_2)、促黄体素(LH)以及生活质量。结果:术前,两组的FSH、E_2、LH均无统计学差异(P>0.05);腹腔镜组术后1月的E_2比术前显著降低,差异具有统计学意义(P<0.05)。术后3月时E_2恢复至术前水平,FSH、LH在术后1、3月均无显著变化,差异无统计学意义(P>0.05)。开腹组术后1、3月的FSH比术前显著升高,差异具有统计学意义(P<0.05)且高于同期腹腔镜组,差异具有统计学意义(P<0.05)。开腹组术后1、3月的E_2比术前显著降低,且低于同期腹腔镜组,差异具有统计学意义(P<0.05)。术前,两组的SF-36总分无统计学意义(P>0.05);腹腔镜组术后1、3月的SF-36总分比术前显著升高,且高于同期开腹组,差异均具有统计学意义(all P<0.05)。结论:腹腔镜子宫肌瘤剔除术能够显著改善患者性激素水平及生活质量。Objective： To investigate the influence of laparoscopic and laparotomy myomectomy on the sex hormones and quality of life of patients. Methods： 96 hysteromyoma patients in Ma＇anshan Central Hospitalfrom January 2015 to June 2017 were selected and,according to the treatment regimen,were divided into laparoscopic group （n = 60） and laparotomy group （n = 36）. The laparoscopic group underwent laparoscopic myomectomy,and the laparotomy group underwent open myomectomy. The follicle stimulating hormone （FSH）,estradiol （E2）,luteinizing hormone （LH） and quality of life were compared between the two groups. Results： There were no significant differences in FSH,E2 and LH between the two groups （P〉 0. 05）. The E2 level in the laparoscopic group was significantly lower at 1-month after operation than that before operation （P〈 0. 05）,and the E2 level returned to preoperative level at 3-month after operation,while there were no significant changes in FSH and LH between 1-month and 3-month after operation （P〉 0. 05）. The FSH in laparotomy group was significantly higher at 1-month and 3-month after operation than that before operation （P〈 0. 05）,and higher than that in the laparoscopic group with statistically significant difference （P〈 0. 05）. The E2 in the laparotomy group was significantly lower at 1-month and 3-month after operation than that before the operation,and lower than that in the laparoscopic group with statistically significant difference （P〈 0. 05）. Before operation,there was no significant difference in SF-36 scores between the two groups （P〉 0. 05）; The total score of SF-36 in the laparoscopic group at 1-month and 3-month after operation was significantly higher than that of the laparotomy group,with statistically significant difference （P〈 0. 05）.Conclusions： Laparoscopic myomectomy can significantly improve the levels of sexual hormones and quality of life of patients.

关 键 词：腹腔镜子宫肌瘤剔除术 开腹子宫肌瘤剔除术 性激素 生活质量 

分 类 号：R737.33[医药卫生—肿瘤]