复明片联合EX-Press引流器植入术治疗新生血管性青光眼疗效及对房水和血清中VEGF、EPO、IL-6表达的影响  

Effect of Fuming Tablets combined with EX-Press drainage implantation in patients with neovascular glaucoma and its influence on the expression of VEGF,EPO and IL-6 in aqueous humor and serum

作　　者：陈博宇[1] 刘迎庆[1] 安慧琴[2] CHEN Boyu;LIU Yingqing;AN Huiqin(Bethune International Peace Hospital,Shijiazhuang 050082,Hebei,China;Hebei General Hospital,Shijiazhuang 050051,Hebei,China)

机构地区：[1]解放军白求恩国际和平医院,河北石家庄050082 [2]河北省人民医院,河北石家庄050051

出　　处：《现代中西医结合杂志》2018年第30期3320-3323,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察复明片联合EX-Press引流器植入术治疗新生血管性青光眼的疗效及对房水和血清中血管内皮生长因子(VEGF)、促红细胞生成素(EPO)和白细胞介素-6(IL-6)表达的影响。方法将单侧新生血管性青光眼患者82例随机平均分为对照组和观察组,每组41例。2组术前均给予左氧氟沙星滴眼液滴眼,对照组单纯给予EX-Press引流器植入,术毕用妥布霉素地塞米松滴眼液滴眼,连用2周。观察组在对照组治疗基础上给予复明片口服,连用1个月。分别检测治疗前和治疗1个月后2组患者的眼压、视力,评价临床有效率,观察2组治疗期间不良反应的发生情况,分别检测治疗前及治疗1个月后2组患者房水和血清中VEGF、EPO和IL-6水平。结果治疗1个月后2组眼压均明显降低(P均<0. 05),视力均明显提高(P均<0. 05),且观察组改变的程度明显大于对照组(P均<0. 05);观察组的临床有效率明显高于对照组(P <0. 05);观察组治疗期间不良反应发生率明显低于对照组(P <0. 05);治疗1个月后2组房水中VEGF、EPO、IL-6水平和血清中VEGF、IL-6水平均明显降低(P均<0. 05),观察组降低的程度均明显大于对照组(P均<0. 05)。结论复明片联合EX-Press引流器植入可以有效降低新生血管性青光眼患者的眼压,提高视力,可能与调节房水和血清中VEGF、EPO和IL-6的表达水平有关。Objective It is to observe the effect of Fuming Tablets combined with EX-Press drainage implantation on neovascular glaucoma and its influence on the expression of vascular endothelial growth factor （VEGF）, erythropoietin （EPO） and interleukin-6 （IL-6） in aqueous humor and serum.Methods Eighty-two patients with unilateral neovascular glaucoma were randomly divided into the control group and the observation group, there were 41 cases in each group. The two groups were given Left Ofloxacin Eye Drops before operation, on the basis, the control group was treated with EX-Press drainage implantation, and Tobramycin and Dexamethasone Ophthalmic Suspension eye drops were used after operation, it will last for 2 weeks; the observation group was given oral Fuming Tablets based on the control group for 1 months. The intraocular pressure and visual acuity of the two groups were detected before and 1 months after treatment. The clinical curative effect was evaluated. The adverse reactions of the two groups during treatment were observed. The levels of VEGF, EPO and IL-6 in aqueous humor and serum of two groups were detected before treatment and 1 months after treatment.Results After 1 months of treatment, the intraocular pressure of the two groups were decreased significantly （all P 〈0.05）, and the visual acuity were increased significantly （all P 〈0.05）, and the degree of change in the observation group was significantly higher than that in the control group （ P 〈0.05）. The clinical effective rate of the observation group was significantly higher than that of the control group （ P 〈0.05）. The incidence of adverse reactions of the observation group was significantly lower than that of the control group （ P 〈0.05）. After 1 month of treatment, the levels of VEGF, EPO, IL-6 in aqueous humor and the levels of VEGF and IL-6 in serum in both groups were significantly decreased （all P 〈0.05）, and the degree of reduction in the observation group was significantly higher than that in the

关 键 词：新生血管性青光眼 EX-Press植入 血管内皮生长因子 促红细胞生成素 白细胞介素-6 

分 类 号：R775.3[医药卫生—眼科]