延安市宝塔区40岁以上常住人口随机抽样筛查脑卒中高危人群血清Hcy水平与性别及年龄差异  

Homocysteine Comparison in Different Gender and Age Groups with High Risk of Stroke of Permanent Residents over Forty Years Old in Baota District of Yan'an

作　　者：邢延芳[1] 张艳[1] 艾江波 刘亚东[1] 马利军[1] XING Yah fang;ZHANG Yan;AI Jiang bo;LIU Ya dong;MA Li jun(Department of Clinical Laboratory,Cardiovascular Specialist Ward,Affiliated Hospital of Yan＇an University,Shaanxi Yan＇an 716000,China)

机构地区：[1]延安大学附属医院心脑血管专科病区检验科,陕西延安716000

出　　处：《现代检验医学杂志》2018年第5期111-114,共4页Journal of Modern Laboratory Medicine

基　　金：延安市惠民计划项目(2014HM-07)

摘　　要：目的分析延安地区不同性别及年龄脑卒中筛查的高危人群血清同型半胱氨酸(Hcy)水平,为脑卒中的防治提供指导。方法按照卫生部的要求,连续六年对延安市宝塔区40岁以上常住人口随机进行卒中的问卷调查、体格检查达54209例,筛出伴高血压的脑卒中高危人群3 427例,其中男性1 324例,占38.63%;女性2 103例,占61.37%;50岁以上占78.79%,男女比63∶100;选取健康体检者104例,应用AU-2700全自动生化分析仪对血清进行血脂、血糖、Hcy水平检测,采用t检验和LSD-t检验,比较各指标组间差异的显著性。结果脑卒中高危人群血脂、血糖、Hcy水平均高于对照组,男性40～49岁组Hcy水平为21.82±15.53μmol/L,50～59岁组Hcy水平为25.45±20.42μmol/L,60～69岁组Hcy水平为24.70±18.90μmol/L,>70岁组Hcy水平为23.85±15.75μmol/L。女性40～49岁组Hcy水平为16.61±11.60μmol/L,50～59岁组Hcy水平为18.40±12.92μmol/L,60～69岁组Hcy水平为18.35±12.88μmol/L,>70岁组Hcy水平为18.18±12.63μmol/L。各年龄组男性的Hcy水平均高于女性,经t检验,差异有统计学意义(t=4.569,6.742,5.732,4.286,均P<0.01);男女Hcy水平较高人群均分布在50～59岁年龄段。结论延安地区脑卒中高危人群血清Hcy水平明显升高,男女在50～59岁年龄段Hcy水平达高峰,应对该年龄段人群进行脑卒中重点防护与干预,以期减低卒中发生的风险。Objective To analyze homocysteine （Hcy） level in different gender and age groups with high risk of stroke and provide theoretical basis and guidance for prevention and control of stroke. Methods The residents in Yan＇an Baota Dstrict were screened. Among them, 54 209 residents, over 40 years old, were surveyed and physically examined in six consecutive years according to the requirements of the Ministry of Health, and among 54 209 residents, 3 427 residents, among them, 1 324 were males,accounting for 38.53%. There were 2 103 cases of females,accounting for 51.37%, 78.79% of them over 50 years old,male to female ratio 53 ： 100, were defined as the groups with high risk of stroke and the serum lipid, blood glucose and serum Hcy levels were detected by AU 2700 Automatic Biochemical Analyzer. Then 104 health examination ca ses were selected. Furthermore, t test and LSD-t test were used to compare the significance of the differences between each indicator group. Results Among the subjects with high risk of stroke, the levels of blood lipids, blood glucose and homocys teine in the high risk population were higher than that in the control group. The homocysteine level in the male aged 40~49 group was 21.82±15.53 μmol/L,aged 50~59 yeaFold group was 25.45±20.42 μmol/L,aged 60~69 yeaFold group was 24.70±18.90 μmol/L,and aged above 70 years old was 23.85±15.75 μmol/L. In the same time the homocysteine level in the female aged 40~49 group was 16.61~11.60 μmol/L,aged 50~59 yeaFold group was 18.40±12.92 μmol/L,aged 60 ~69 yeaFold group was 18.35±12.88 μmol/L,and aged above 70 years old was 18.18±12.63 μmol/L. Furthermore,the serum Hcy levels were higher in male ones than female ones in different age groups,and the difference was statistically sig nificant （t=4. 569,6. 742,5. 732,4. 286,all P〈0.01）. Moreover,the serum Hcy levels of the residents at 50 to 59 years oldwas the highest in both men and women groups. Conclusion Generally, the level of serum homocysteine in the high risk population in the

关 键 词：脑卒中 同型半胱氨酸 性别 年龄 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R446.112[医药卫生—临床医学]