遗传与表观遗传及其相互作用在大骨节病中的研究进展  

Research progress of genetic and epigenetic and their interactions in Kashin-Beck disease

作　　者：张迪 熊咏民 ZHANG Di;XIONG Yongmin(Research Center of Endemic Diseases,Public Health and Health Science Center ofXi an Jiaotong University,Key Laboratory of Trace Elements and Endemic Diseases ofHealth and State Health Protection Commission,Xi an 710061,China)

机构地区：[1]西安交通大学医学部公共卫生学院地方病研究所国家卫健委微量元素与地方病重点实验室,陕西西安710061

出　　处：《国外医学（医学地理分册）》2018年第4期357-360,共4页Foreign Medical Sciences：Section of Medgeography

基　　金：国家自然科学基金资助项目(No.81773372;81573104)

摘　　要：大骨节病(Kashin-Beck disease,KBD)是一种地方性、慢性骨关节病,致残率很高,严重危害人民健康,至今病因未明。目前研究表明,该病发病与环境因素相关,近年来有关大骨节病遗传、表观遗传学及其相互作用成为研究热点。本文从遗传,表观遗传及其相互作用方面对大骨节病近年来的研究进展进行综述,旨在为进一步探索大骨节病的发病机制提供参考依据。Kashin-Beck disease （KBD） is a endemic and chronic osteoarthrosis. The disability is very high, which seriously endangers people s health, and its causes remain unclear. Recent studies show that the disease is associated with environmental factors. In recent years, the genetic, epigenetics and interaction of Kaschin Beck disease have become a research focus. In this paper, We review the KBD from the aspects of heredity, epigenetic inheritance and their interaction, in order to provide a scientific basis for further exploration of the pathogenesis of Kaschin Beck disease.

关 键 词：大骨节病 环境因素、遗传 表观遗传 相互作用 

分 类 号：R155[医药卫生—营养与食品卫生学]