大骨节病病因及发病机制研究进展与展望  

The progress and prospect of the etiology and pathogenesis of Kashin-Beck disease

作　　者：李新楠 陈群[1] LI Xinnan;CHEN qun(Medical School of Xi an Jiaotong University,Xi an 710061,China)

机构地区：[1]西安交通大学医学部,陕西西安710061

出　　处：《国外医学（医学地理分册）》2018年第4期361-364,共4页Foreign Medical Sciences：Section of Medgeography

基　　金：国家自然科学基金资助项目(No.81673115)

摘　　要：大骨节病是一种病因与发病机制未明、致残率极高的地方性骨关节病。近年来多项研究成果对其原有的低硒学说、水中有机物中毒学说、毒素中毒学说等假说做出了补充与更新,尤其是在分子生物学领域有了更多突破性进展。本文就现有的大骨节病的病因与发病机制研究成果做一综述。Kashin-Beck disease（KBD） is an endemic and deforming osteoarticular disease.The pathogenesis of KBD is not clear. In recent years, there are many achievements updating the three past etiological hypotheses：low selenium hypotheses, water organic compound poisoning hypothesis and food fungi toxin poisoning hypothesis. In particular, there is a big breakthrough in molecular biology for KBD. This paper summarized the important progress in the etiology and pathogenesis of KBD.

关 键 词：大骨节病 病因 发病机制 进展 展望 

分 类 号：R155[医药卫生—营养与食品卫生学]