miRNA-126对多种肿瘤发生发展的影响及其作用机制的探讨  

The effect of miRNA-126 on the development of multiple tumors and its mechanism of action

作　　者：邓晓卓 董甜甜[1] 喻玲玲[1] 刘习建 陈静文 DENG Xiaozhuo;DONG Tiantian;YU Lingling;LIU Xijian;CHEN Jingwen(Medical College of Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学医学院,宜昌443002

出　　处：《生命的化学》2018年第4期570-576,共7页Chemistry of Life

基　　金：国家自然科学基金项目(1215181)

摘　　要：miRNA是一类高度保守的非编码RNA,其作为一种重要的转录后基因调控元件,在肿瘤的发生发展过程中发挥重要的作用。miRNA-126被认为是一种肿瘤抑制因子,对多种肿瘤的增殖、迁移、侵袭及预后具有显著的抑制作用。本文主要对miRNA-126在肿瘤方面的研究新进展作一综述。MiRNAs are highly conserved non-coding RNAs. As an important post-transcriptional gene regulatory element, miRNAs play an important role in the development of tumors. MiRNA-126 is considered to be a tumor suppressor and has a significant inhibitory effect on the proliferation, migration, invasion, and prognosis of various tumors. This article mainly reviews recent advances in the research of miRNA-126 in cancer.

关 键 词：miRNA-126 调控元件 肿瘤 

分 类 号：R730.231[医药卫生—肿瘤]