补阳还五汤治疗女性精神分裂症焦虑症状临床观察  

Clinical Observation of Buyang Huanwu Tang for Anxiety Symptoms of Female Schizophrenia

作　　者：林巧 纪家武 官芳萍 罗兰珠 胡耀华 丘骏 陈文辉 LIN Qiao;JI Jiawu;GUAN Fangping;LUO Lanzhu;HU Yaohua;QIU Jun;CHEN Wenhui

机构地区：[1]福州神经精神病防治院,福建福州350008

出　　处：《新中医》2018年第9期58-61,共4页New Chinese Medicine

基　　金：福州市科技计划项目(2016-S-126-1)

摘　　要：目的:观察补阳还五汤治疗女性精神分裂症焦虑症状的临床疗效。方法:将精神分裂症女性患者7 0例随机分为对照组和观察组各3 5例。对照组予常规抗精神病药物治疗,观察组在对照组基础上服用补阳还五汤,2组均治疗6周。比较2组临床疗效,治疗前、治疗后2周、4周、6周汉密顿焦虑量表(HAMA)评分和焦虑因子分(包括躯体性焦虑和精神性焦虑),评估2组不良反应发生情况。结果:治疗6周后,愈显率观察组为7 7.1%,对照组为3 1.4%,2组比较,差异有统计学意义(P<0.05)。治疗2周、4周、6周后,2组HAMA评分与前一时间点比较均下降(P<0.05);治疗2周后,2组HAMA评分比较,差异无统计学意义(P>0.05),治疗4周、6周后,观察组HAMA评分均较对照组下降更明显(P<0.05)。治疗2周、4周、6周后,对照组精神性焦虑评分、观察组躯体性焦虑评分、精神性焦虑评分均较治疗前下降(P<0.05),对照组躯体性焦虑评分与治疗前比较,差异无统计学意义(P>0.05)。治疗2周、4周、6周后,2组精神性焦虑评分均较同组前一时间点降低(P<0.05),同一时间点观察组精神性焦虑评分和对照组比较,差异均无统计学意义(P>0.05);治疗4周、6周后,观察组躯体性焦虑评分与对照组比较均降低(P<0.05)。2组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论:补阳还五汤能改善精神分裂症患者的焦虑症状,对躯体性焦虑的改善更明显,可用于精神分裂症的辅助治疗。Objective： To observe the clinical effect of Buyang Huanwu tang for anxiety symptoms of female schizophrenia.Methods：Divided 70 cases of female patients with schizophrenia into the control group and the observation group randomly,35 cases in each group. The control group was given the routine antipsychotic drugs,while the observation group additionally received the oral administration of Buyang Huanwu tang. The treatment for both groups lasted for 6 weeks. Compared the clinical effect, scores of Hamilton anxiety scale（HAMA） and anxiety scores（including somatic anxiety and psychic anxiety） in both groups before treatment and after treatment for 2 weeks,4 weeks and 6 weeks,and evaluated the occurrence of adverse reactions in both groups. Results：After 6 weeks of treatment,the total obvious effective rate was 77.1% in the treatment group and 31.4% in the control group,difference being significant（P〈0.05）. After 2, 4 and 6 weeks of treatment, the scores of HAMA in both groups were all lower than those in the previous time points（P〈0.05）; after 2 weeks of treatment, comparing the scores of HAMA in the two groups, there was no significant difference being found（P〈0.05）,and after 4 and 6 weeks of treatment,the scores of HAMA in the observation group were decreased more significantly than those in the control group（P〈0.05）. After 2,4 and 6 weeks of treatment,the psychic anxiety score in the control group,and somatic anxiety score and psychic anxiety score in the observation group were lower than those before treatment（P〈0.05）;comparing the somatic anxiety score in the control group with that before treatment,there was no significant difference being found（P〈0.05）. After 2,4 and 6 weeks of treatment,the psychic anxiety scores of both groups were all lower than those of the same group in the previous time points（P〈0.05）;comparing the psychic anxiety scores of the observation group in the same time point with that in the control group,there were no significant differen

关 键 词：精神分裂症 焦虑 补阳还五汤 汉密顿焦虑量表(HAMA) 躯体性焦虑 精神性焦虑 

分 类 号：R749.3[医药卫生—神经病学与精神病学]