错配修复在DNA双链断裂修复中的作用  

Mismatch repair during DNA double-strands break repair

作　　者：王旭[1] 孟祥宁[1] Wang Xu;Meng Xiangning(Laboratory of Medical Genetics,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学医学遗传学研究室,150081

出　　处：《国际遗传学杂志》2018年第4期279-283,288,共6页International Journal of Genetics

基　　金：国家国际科技合作专项（2013DFA31610）;国家自然科学基金（81572915）

摘　　要：DNA双链断裂（DNA double strand breaks,DSBs）是最严重的DNA损伤之一,细胞中主要存在两种DSBs的修复途径,同源重组和非同源末端连接.错配修复（mismatch re-pair,MMR）通过纠正在DNA复制和重组过程中产生的碱基错配和插入/缺失错配维持基因组的稳定性.MMR还可招募同源重组中的关键因子,阻止同源重组中异源双链形成重组以及纠正非同源末端连接中形成的错配,因此错配修复参与DSBs的修复并发挥重要作用,保证了修复的准确性.本文综述了错配修复和DNA双链断裂修复的机制,并探讨了错配修复在DNA双链断裂修复中的作用.DNA double strand break （ DSB ） is one of the most serious DNA damages . Homolo-gous recombination and non-homologous end joining are the two pathways repairing the DSBs in cells . Mismatch repair （ MMR ） plays a key role in maintaining genomic stability through correcting base-base mismatches and insertion/deletion mispairs generated during DNA replication and recombination . Addition-ally , MMR can recruit key factors in HR pathway , refuse the recombination between heteroduplex and cor-rect the mismatches in non-homologous end joining . Therefore , MMR has an important role in DSBs re-pair , ensuring the accuracy of DSBs repair . This review summarizes the mechanism of MMR and DSBs re-pair , and discusses the role of MMR in DSBs repair .

关 键 词：错配修复 DNA双链断裂修复 同源重组 非同源末端连接 

分 类 号：R394[医药卫生—医学遗传学]