电针百会穴治疗帕金森病轻度认知功能障碍临床观察  

Effect of Electroacupuncture at Baihui Point in Treatment of Mild Cognitive Impairment in Parkinson's Disease

作　　者：林志诚 游咏梅[1] 杨珊莉 钟慧 叶晓倩 江一静[1] LIN Zhi-cheng;YOU Yong-mei;YANG Shan-li;ZHONG Hui;YE Xiao-qian;JIANG Yi-jing(Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fujian Fuzhou 350003,China;Fujian University of Traditional Chinese Medicine,Fujian Fuzhou 350000,China)

机构地区：[1]福建中医药大学附属康复医院,福建福州350003 [2]福建中医药大学,福建福州350000

出　　处：《安徽中医药大学学报》2018年第5期31-35,共5页Journal of Anhui University of Chinese Medicine

基　　金：国家自然科学基金项目(81574048);福建省中医药科研项目(2017FJZYLC506)

摘　　要：目的观察电针百会穴对帕金森病轻度认知功能障碍(mild cognitive impairment in Parkinsons disease,PD-MCI)患者认知功能的影响。方法将37例PD-MCI患者随机分为治疗组(n=19)和对照组(n=18),对照组给予认知训练及药物干预,治疗组在此基础上给予百会穴电针治疗。治疗前后及随访期间分别采用连线测试(trial making test,TMT)评价PD-MCI患者的执行功能,采用蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)评价总体认知功能,采用帕金森病统一评分量表(unified Parkinsons disease rating scale,UPDRS)-Ⅱ、UPDRS-Ⅲ评价运动能力及日常生活能力。结果与治疗前比较,两组治疗后TMT-A、TMT-B显著降低(P<0.05),MoCA评分显著升高(P<0.05),仅治疗组治疗后UPDRS-Ⅱ评分显著降低(P<0.05);与治疗后比较,随访期两组TMT-A、TMT-B和UPDRS-Ⅱ、UPDRS-Ⅲ评分均呈上升趋势,MoCA评分呈下降趋势,其中对照组随访期TMT-B以及两组随访期UPDRS-Ⅲ评分反而显著高于治疗前(P<0.05)。与对照组比较,治疗后和随访期治疗组TMT-A、TMT-B显著降低(P<0.05),MoCA评分显著升高(P<0.05),治疗后UPDRS-Ⅱ评分显著降低(P<0.05)。结论在常规西医治疗基础上,电针百会穴能够改善PD-MCI患者的认知功能。Objective To investigate the effect of electroacupuncture at Baihui point on cognitive function in patients with mild cognitive impairment in Parkinson＇s disease （PD-MCI）. Methods A total of 37 patients with PD-MCI were randomly divided into treatment group with 19 patients and control group with 18 patients. The patients in the control group were given cognitive training and drug treatment, and those in the treatment group were given electroacupuncture at Baihui point in addition to the treatment in the control group. Before and after treatment and during follow-up, the Trial Making Test （TMT） was used to evaluate executive function; the Montreal Cognitive Assessment （MoCA） was used to evaluate cognitive function; the Unified Parkinson＇s Disease Rating Scale-Ⅱ （UPDRS-Ⅱ） and Unified Parkinson＇s Disease Rating Scale-Ⅲ （UPDRS-Ⅲ） were used to assess motor ability and activities of daily living. Results After treatment, both groups had significant reductions in TMT-A and TMT-B （P〈0.05） and a significant increase in MoCA score （P〈0.05）, and only the treatment group had a significant reduction in UPDRS-Ⅱ score （P〈0.05）. During follow-up, both groups had increases in TMT-A, TMT-B, UPDRS-Ⅱ score, and UPDRS-Ⅲ score and a reduction in MoCA score; from before treatment to follow-up, the control group had significant increases in TMT-B and UPDRS-Ⅲ score and the treatment group had a significant increase in UPDRS-Ⅲ score （P〈0.05）. Compared with the control group, the treatment group had significant reductions in TMT-A and TMT-B and a significant increase in MoCA score after treatment and during follow-up （P〈0.05）, as well as a significant reduction in UPDRS-Ⅱ score after treatment （P〈0.05）. Conclusion In addition to conventional Western medicine treatment, electroacupuncture at Baihui point can improve the cognitive function of patients with PD-MCI.

关 键 词：帕金森病 轻度认知障碍 电针 百会 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R245[医药卫生—临床医学]