治疗前18F－FDG PET/CT SUVmax对Ⅰ～Ⅱ期鼻型NK/T细胞淋巴瘤的预后判断价值  

Prognostic value of pretreatment 18F-FDG PET/CT SUVmax on stage Ⅰ-Ⅱ extranodal nasal type natural killer/T-cell lymphoma

作　　者：张亚飞[1] 王珍 林丽莉[1] 赵欣[1] 刘侃峰[1] 朱云奇 王华涛[1] 诸欢燕[1] 赵葵[1] Zhang Yafei;Wang Zhen;Lin Lili;Zhao Xin;Liu Kanfeng;Zhu Yun-qi;Wang Huatao;Zhu Huanyan;Zhao Kai(PET center,the First Affiliated Hospital,Medical School of Zhejiang University,Hangzhou 310003,China)

机构地区：[1]浙江大学医学院附属第一医院PET中心,杭州310003

出　　处：《中华核医学与分子影像杂志》2018年第9期602-604,共3页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：浙江省基础公益研究计划（LGF18h180001）

摘　　要：目的探讨治疗前18F－脱氧葡萄糖（FDG） PET/CT显像对鼻型自然杀伤/T细胞淋巴瘤（ENKTL）预后的判断价值。方法回顾性分析2013年2月至2016年2月经病理证实、Ann Arbor分期为Ⅰ～Ⅱ期的ENKTL患者35例，其中男20例、女15例，平均年龄45岁。患者治疗前均行18F－FDG PET/CT显像，记录病灶最大标准摄取值（SUVmax），计算淋巴瘤国际预后指数（IPI），记录患者血清乳酸脱氢酶（LDH）及免疫组织化学结果等，并随访2年。采用Fisher确切概率法及2种属性独立性χ2检验分析病灶SUVmax与无进展生存（PFS）、病理特征及IPI的关系。结果35例ENKTL患者中，18例进展，17例无进展。病灶SUVmax≥12.2的ENKTL患者较SUVmax〈12.2者预后差（P＝0.001）。SUVmax与细胞增殖核抗原Ki－67相关（r＝0.701，P＝0.001），并与CD56阳性表达（r＝0.393，P＝0.032）及IPI（r＝0.787，P〈0.01）相关。SUVmax、Ki－67、CD56和IPI均对PFS有影响（均P〈0.05）。结论18F－FDG PET/CT显像SUVmax可作为预测ENKTL预后的重要指标。ObjectiveTo investigate the prognostic value of pretreatment 18F-fluorodeoxyglucose （FDG） PET/CT imaging on extranodal nasal type natural killer/T-cell lymphoma （ENKTL）.MethodsThirty-five patients （20 males, 15 females, average age 45 years） diagnosed as Ann Arbor stage Ⅰ-ⅡENKTL from February 2013 to February 2016 were retrospectively analyzed. All patients were pathologically confirmed and underwent 18F-FDG PET/CT before treatment. The maximum standardized uptake value （SUVmax）, international prognostic index score （IPI）, serum lactate dehydrogenase （LDH）, and immunohistochemical results were recorded. Patients were followed up for 2 years. The relationships between SUVmax, progression-free survival （PFS）, pathological features and IPI were assessed using Fisher exact test.ResultsThere were 18 ENKTL patients with progression, and 17 had no progression. Patients with SUVmax≥12.2 had worse prognosis than those with SUVmax〈12.2 （P=0.001）. There were correlations between SUVmax and Ki-67 （r=0.701, P=0.001）, SUVmax and CD56 （r=0.393, P=0.032）, SUVmax and IPI （r=0.787, P〈0.01）, respectively. It was also found that SUVmax, Ki-67, CD56 and IPI were related to PFS （all P〈0.05）.ConclusionSUVmax of 18F-FDG could be used as an important prognostic indicator for early ENKTL.

关 键 词：淋巴瘤 结外NK-T细胞 预后 正电子发射断层显像术 体层摄影术 X线计算机 脱氧葡萄糖 

分 类 号：R733[医药卫生—肿瘤] R730.44[医药卫生—临床医学]