左、右半结肠癌患者临床病理特点及预后差异分析  

Clinical and Pathological Features and Prognosis of Patients with Left and Right Colon Cancer

作　　者：李院江[1] 罗林海[1] LI Yuan-jiang;LUO Lin-hai(Department of Gastrointestinal Surgery,Yuxi People＇s Hospital,Yuxi,Yunnan Province,653100 China)

机构地区：[1]玉溪市人民医院胃肠外科,云南玉溪653100

出　　处：《中外医疗》2018年第24期20-22,共3页China & Foreign Medical Treatment

摘　　要：目的研究对比左、右半结肠癌患者临床病理特点及预后差异。方法回顾性分析2010年5月—2013年6月该院肿瘤科收治的210例结肠癌患者的临床资料,对比左半结肠癌患者(76例)与右半结肠癌患者(134例)的流行病学特征、病理特点及预后生存情况。结果左、右半结肠癌患者在男女比例、年龄、首发症状上均差异有统计学意义(χ2=21.960,P<0.05),右半结肠癌患者以高龄者居多,平均年龄为(67.39±2.45)岁,首发症状以腹痛腹泻(80.60%)为主。与左半结肠癌相比,右半结肠癌具有肿瘤直径大,有74.63%的患者肿瘤直径≥5 cm(χ2=13.744),溃疡型患者占79.85%(χ2=10.135),同时具有高分化(5.97%)(χ2=11.740)、淋巴转移(36.57%)(χ2=8.192)、中晚期特点,病理特点比较明显,差异有统计学意义(P<0.05)。左、右半结肠癌在1年生存率(94.12%vs 95.83%)(χ2=0.004)、3年生存率(83.82%vs 81.67%)(χ2=0.065)上差异无统计学意义(P>0.05),右半结肠癌患者5年生存率(59.17%)明显低于左半结肠癌患者(75.00%),差异有统计学意义(χ2=13.657,P<0.05)。结论左、右半结肠癌患者临床病理特征差异明显,右半结肠癌患者的生存预后不理想,5年生存率低于左半结肠癌患者。Objective To compare the clinicopathological features and prognosis of patients with left and right colon cancer.Methods The clinical data of 210 patients with colon cancer admitted to the hospital from May 2010 to June 2013 wereretrospectively analyzed. The clinical data, disease characteristics, pathological features, and prognosis of survival of patientswith left colon cancer （76 cases） and right colon cancer （134 cases） were compared. Results There were significant differences in the proportion of males and females, age, and initial symptoms between the right and left colon cancer patients （P〈0.05）. The right-sided colon cancer patients were mostly elderly people with an average age of （67.39±2.45） years old. Diarrhea in abdominal pain （80.60%） （X^2= 21.960） dominated. Compared with left colon cancer, right colon cancer has a largetumor size, with a tumor diameter of ≥5 cm （X^2=13.744） in 74.63% of patients, 79.85% in ulcerative patients （X^2=10.135）,and high differentiation （5.97%）（X^2=11.740）, lymph node metastasis （36.57%） （X^2=8.192）, and late-stage characteristics thepathological features were obvious,the difference was statistically signficant（P〈0.05）. There was no significant difference inleft and right colon cancer at 1-year （94.12% vs 95.83%） （X^2=0.004） and 3-year survival （83.82% vs 81.67%） （X^2=0.065）（P〉0.05）. The 5-year survival rate of right colon cancer patients （59.17%） was significantly lower than that of left coloncancer patients （75.00%）, and the difference was statistically significant （X^2=13.657, P〈0.05）. Conclusion The clinical andpathological features of patients with left and right colon cancer are significantly different. The survival and prognosis ofpatients with right colon cancer are not ideal. The 5-year survival rate is lower than that of patients with left colon cancer.

关 键 词：结肠癌 病理特点 预后 

分 类 号：R735.3[医药卫生—肿瘤]