P16、Ki67在子宫肌瘤和富于细胞性平滑肌瘤中的表达及临床意义  

Expression and Clinical Significance of P16 and Ki67 in Uterine Fibroids and Cellular Leiomyomata

作　　者：孙美玲 张蓓 SUN Meiling;ZHANG Bei(Xuzhou Medical University, Xuzhou Jiangsu 221000, China)

机构地区：[1]徐州医科大学,江苏徐州221000 [2]徐州医科大学附属徐州中心医院妇产科

出　　处：《解放军预防医学杂志》2018年第9期1165-1167,1171,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：江苏省淮安市科技支撑计划(No.HAS2012027)

摘　　要：目的研究P16、Ki67在子宫肌瘤(UL)和富于细胞性平滑肌瘤(CL)中的表达及临床意义。方法选取2017年8月-2018年3月在我院进行妇科手术治疗的患者,在术后通过病理学证实有60例为普通型UL患者,30例属于CL患者。取60例肌瘤组织标本,30例富于细胞性平滑肌瘤组织标本,提取相应的60例瘤旁肌层组织,观察P16、Ki67在瘤旁肌层组织、肌瘤组织、富于细胞性平滑肌组织中的阳性表达情况,分析子宫肌瘤和子宫富于细胞性平滑肌中的P16、Ki67表达和临床病理特征关系。结果富于细胞性平滑肌组的P16、Ki67阳性率显著高于肌瘤组、瘤旁肌层组,差异具有统计学意义(P<0.05)。在子宫肌瘤患者中年龄<45岁和≥45岁的P16、Ki67阳性表达率比较无显著差异(P>0.05),在子宫肌瘤数量为单发和多发的子宫肌瘤患者中P16、Ki67阳性表达率比较无明显差异(P>0.05),在子宫肌瘤结节大小≤4 cm、>4 cm子宫肌瘤患者中P16、Ki67阳性表达率比较无明显差异(P>0.05)。在子宫富于细胞性平滑肌中年龄<45岁和≥45岁的P16、Ki67阳性表达率比较无显著差异(P>0.05),在子宫肌瘤数量为单发和多发的子宫富于细胞性平滑肌中P16、Ki67阳性表达率比较无明显差异(P>0.05),在子宫肌瘤结节大小≤4 cm、>4 cm子宫富于细胞性平滑肌患者中P16、Ki67阳性表达率比较无明显差异(P>0.05)。结论子宫富于细胞性平滑肌瘤组织中的P16、Ki67阳性表达率显著高于瘤旁肌层组织、子宫肌瘤组织,表明在判断UL、CL预后时,可通过P16、Ki67在UL与CL中的表达作出预测。Objective To study the expression and clinical significance of P16 and Ki67 in uterine fibroids（ UF） and cellular leiomyoma（ CL）. Methods Patients undergoing gynecological surgery in our hospital between August 2017 and March 2018 were selected. Sixty cases of common UF were confirmed by pathology. Also,there were thirty cases of CL patients. Samples were taken from fibroid tissues of the 60 cases and from cellular leiomyoma tissues of the 30 cases. Paramyomuscular tissues were also taken from the 60 cases of UF. Expressions of P16 and Ki67 in the tumor myometrial tissue,fibroid tissue and CL tissue were observed and their clinicopathological characteristics were analyzed.Results The positive rates of P16 and Ki67 in the CL group were significantly higher than those in the fibroid group and the paratumor muscle group,and the difference was statistically significant（ P〈0.05）. The positive expression rates of P16 and Ki67 were not significantly different between patients with uterine fibroids under 45 years of age and those who were 45 years old or above（ P〈0.05）. The positive expression rates of P16 and Ki67 were not significantly different between patients with uterine fibroid nodule size of 4 cm or under 4 cm and those whose uterine fibroid nodule size was above 4 cm（ P〈0.05）. The positive rates of P16 and Ki67 in single and multiple uterine fibroids were not significantly different（ P〈0. 05）. Conclusion The positive rates of P16 and Ki67 in cellular leiomyoma are significantly higher than those in tissues of peritumoral leiomyoma and uterine fibroids,indicating that P16 and Ki67 can help predict the prognosis of UF and CL.

关 键 词：P16 KI67 子宫肌瘤 富于细胞性平滑肌瘤 

分 类 号：R737.33[医药卫生—肿瘤]