乳腺癌术后巩固化疗感染患者的相关性分析及其干预措施研究  

The Correlation Analysis and Intervention Measures of Breast Cancer Patients with Postoperative Chemotherapy Infection

作　　者：陈剑[1] 牛高华 CHEN Jian;NIU Gaohua.(The First Affiliated Hospital of He＇nan University of Traditional Chinese Medicine,Zhengzhou,45000)

机构地区：[1]河南中医药大学第一附属医院,450000

出　　处：《实用癌症杂志》2018年第10期1704-1707,共4页The Practical Journal of Cancer

摘　　要：目的探讨导致乳腺癌术后巩固化疗患者的感染情况,并对其影响因素进行相关性分析,同时提出相应的干预措施。方法分析乳腺癌术后巩固化疗232例患者的感染情况,并收集感染者的临床资料,对其进行单多因素分析。结果 232例乳腺癌术后巩固化疗患者中感染率为16. 38%,以呼吸道感染和皮肤软组织感染为主,分别为42. 11%和31. 58%;其中革兰阴性菌株感染最常见,占55. 77%,其中肺炎克雷伯菌所占比较最大,为26. 92%;主要集中在化疗的第3个和第4个疗程,分别为34. 21%和36. 84%;经单因素分析发现,乳腺癌术后巩固化疗感染与年龄、TNM分期、伴随疾病种类和骨髓抑制情况相关,差异具有统计学意义(P <0. 05);经多因素分析得知,年龄> 55岁、TNMⅢ期、伴随疾病种类> 2及Ⅲ级骨髓抑制是乳腺癌术后巩固化疗感染患者的主要危险因素(P <0. 05)。结论乳腺癌术后巩固化疗感染率较高,其感染与年龄> 55岁、TNMⅢ期、伴随疾病种类> 2及Ⅲ级骨髓抑制相关性大,临床医护人员须加强对这类人群的重视,有针对性地制定干预措施,降低感染率,提高乳腺癌的治疗效果。Objective To investigate the infection of breast cancer patients after postoperative chemotherapy,and to analyze the related factors,and to put forward the corresponding intervention measures. Methods Analyzed the infection status of 232 cases of breast cancer after chemotherapy,collected the clinical data of the infected patients,and carried out single factor analysis. Results The infection rate of 232 cases breast cancer after postoperative chemotherapy was 16.38%,it gave first place to respiratory tract infection and skin soft tissues infection,and they were 42.11% and 31.58% respectively;the Gram-negative bacteria infection was the most common,accounting for 55.77%,Klebsiella pneumoniae accounted for 26.92%;It mainly focused on the third courses and fourth courses of chemotherapy,and they were 34.21% and 36.84% respectively;the single factor analysis showed that the infection rate of breast cancer after operation was related to age,TNM stage,the type of concomitant diseases and the suppression of bone marrow,and the difference was statistically significant（ P〈0.05）;the multivariate analysis showed that age〉55 years,stage TNM-stage Ⅲ,the type of concomitant diseases〉2 and grade Ⅲ myelosuppression were the major risk factors of postoperative chemotherapy in breast cancer patients（ P〈0.05）. Conclusion The infection rate of breast cancer postoperative chemotherapy is high,it is related to age〉55 years,stage TNM-stage Ⅲ,the type of concomitant diseases〉2 and grade Ⅲ myelosuppression,medical staff should be strengthened to these people＇s attention,to develop targeted interventions and reduce the infection rate,improve the therapeutic effect of breast cancer.

关 键 词：乳腺癌 术后化疗 感染 影响因素 干预措施 

分 类 号：R737.9[医药卫生—肿瘤]