青光眼基因治疗研究进展  

Advances in gene therapy of glaucoma

作　　者：彭晋妍 钟佳宁 王辉[3] PENG Jin-yan;ZHONG Jia-ning;WANG Hui(Gannan Medical University 1.Postgraduate Student,Grade 2015;Research Center;Department of Ophthalmology,The First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院 [2]赣南医学院科研中心,江西赣州341000 [3]赣南医学院第一附属医院眼科,江西赣州341000

出　　处：《赣南医学院学报》2018年第8期830-834,共5页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(编号:81760160);江西省教育厅科学技术研究项目(编号:GJJ170882);赣南医学院课题(编号:QD201605)

摘　　要：青光眼是目前临床上常见的不可逆性致盲眼病之一,其危害严重,迄今尚无有效的治疗方法。近年来,大量的研究发现,其发病机制与相关基因结构和功能的异常密切相关。随着人们对青光眼发病相关基因的深入研究,以及基因治疗试验在大鼠等哺乳动物模型中的广泛开展,基因治疗将成为未来治愈青光眼的重要方向之一。因此,本文将对青光眼基因治疗的最新研究进行综述。Glaucoma is a common and seriously harmful disease that can cause irreversible blindness, and so far there is no effective treatment to prevent the development of the disease. In recent years, a large number of studies have found that the pathogenesis is closely related to the structural and functional abnormalities of related genes. With the further research on the gene related to the pathogenesis of glaucoma, and the gene therapy trials widely carried out in mammals such as rats, gene therapy will become one of the important directions for the future treatment of glaucoma. Therefore, this article will review the latest research on gene therapy of glaucoma.

关 键 词：青光眼 视网膜神经节细胞 基因治疗 

分 类 号：R775[医药卫生—眼科]