血清Ox-LDL、Fib、PAI-1在急性缺血性脑卒中的表达及意义  

Expressions and Significance of Serum Ox-LDL,Fib and PAI-1 in Acute Ischemic Stroke

作　　者：袁野[1] 唐柚青[1] YUAN Ye;TANG Youqing(Department of Emergency,General Hospital of Guangzhou Military Command,Guangzhou 510010,China)

机构地区：[1]广州军区广州总医院急诊科,广州510010

出　　处：《解放军预防医学杂志》2018年第8期1012-1014,1039,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：广东省科技项目计划;编号2016B031500014(粤科规划字【2016】98号)

摘　　要：目的探讨血清氧化型低密度脂蛋白(Ox-LDL)、纤维蛋白原(Fib)、Ⅰ型纤溶酶原激活抑制剂(PAI-1)在急性缺血性脑卒中患者中的表达及意义。方法选取2017年1月-2017年12月在我院急诊科治疗的急性缺血性脑卒中患者267例(观察组),同时选取行头部影像学检查无异常者100例作为对照组,检测并对比两组血清Ox-LDL、Fib、PAI-1水平。结果观察组血清Ox-LDL、Fib、PAI-1分别为(72.01±8.28)μg/dl、(4.40±1.13)g/L和(52.29±8.10)mg/L,明显高于对照组(P<0.05);重型患者血清Ox-LDL、Fib、PAI-1分别为(83.02±9.10)μg/dl、(5.08±1.07)g/L和(60.10±9.22)mg/L,明显高于中型组和轻型组(P<0.05);预后不良患者血清Ox-LDL、Fib、PAI-1分别为(85.01±9.15)μg/dl、(5.00±1.22)g/L和(59.11±9.21)mg/L,明显高于预后良好患者(P<0.05)。结论急性缺血性脑卒中患者血清Ox-LDL、Fib、PAI-1明显升高,与患者病情程度、预后有一定关系,值得进一步研究。Objective To investigate the expressions and significance of serum oxidized low density lipoprotein（ Ox-LDL）,fibrinogen（ Fib） and type Ⅰ plasminogen activator inhibitor（ PAI-1） in patients with acute ischemic stroke. Methods Two hundred and sixty-seven cases of acute ischemic stroke（ the observation group） were selected from January 2017 to December 2017 in the Emergency Department of our hospital,and another 100 cases with no abnormality in the head imaging examination were selected as the control group. Serum levels of Ox-LDL,Fib and PAI-1 were detected in both groups.Results The serum levels of Ox-LDL,Fib and PAI-1 in the observation group were（ 72. 01 ± 8.28） μg/dl,（ 4. 40 ± 1. 13） g/L and（ 52. 29 ±8.10） mg/L respectively,which were significantly higher than those in the control group（ P〈0. 05）. The serum levels of Ox-LDL,Fib and PAI-1 of severe patients were（ 83.02±9.10） μg/dl,（ 5.08± 1.07） g/L and（ 60.10± 9.22） mg/L respectively,which were significantly higher than those in the medium and the mild group（ P〈0.05）. These levels in patients with poor prognosis were（ 85.01±9.15） μg/dl,（ 5.00±1.22） g/L and（ 59.11±9.21） mg/Lrespectively,which were significantly higher than those with good prognosis（ P〈0.05）.Conclusion Serum Ox-LDL,Fib and PAI-1 levels in patients with acute ischemic stroke are increased significantly and related to the severity and prognosis of the patients,which are worthy of further study.

关 键 词：氧化型低密度脂蛋白 纤维蛋白原 Ⅰ型纤溶酶原激活抑制剂 急性缺血性脑卒中 

分 类 号：R743.3[医药卫生—神经病学与精神病学]