滋肾健脾化瘀方对复发性流产患者凝血功能的影响  

Effect of Zishen Jianpi Huayu Prescription on Blood Coagulation Function in Patients with Recurrent Spontaneous Abqrtion

作　　者：宋艳丽[1] 孙自学[1] 门波[1] 张华[1] SONG Yan-li;SUN Zi-xue;MEN Bo;ZHANG Hua(Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China)

机构地区：[1]河南省中医院

出　　处：《中国实验方剂学杂志》2018年第19期195-200,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：河南省中医药科学研究专项(2017XY3004)

摘　　要：目的：观察滋肾健脾化瘀方对复发性流产脾肾两虚、血瘀阻络证患者凝血功能的影响,探求其作用机制。方法：将105例符合条件的患者随机分为A组,B组和C组,各35例。分别给予滋肾健脾化瘀方、阿司匹林片、低分子量肝素钙。观察各组患者治疗前后中医辨证＂数堕胎＂脾肾两虚、血瘀阻络证量表（中医证候）评分,凝血功能[部分纤溶酶原激活物抑制剂-1（PAI-1）,活化部分凝血活酶时间（APTT）,凝血酶时间（TT）,纤维蛋白原（FIB）,组织型纤溶酶原活化因子（t-PA）,凝血酶原时间（PT）,D-二聚体（D-D）,组织因子（TF）,纤维蛋白肽A（FPA）,狼疮抗凝物质（LA）,活化蛋白S（PS）,活化蛋白C（PC）,抗心磷脂抗体（ACA）,血小板聚集功能（PAF）,纤维蛋白原（Fig）,纤溶酶-抗纤溶酶复合物（PAP）,凝血酶原片段（F1＋2）,血小板α颗粒膜糖蛋白-140（GMP-140）,抗凝血酶（AT）,血酶-抗凝血酶复合物（TAT）];比较各组有效率和不良反应发生率。结果：A组总有效率84.4%,高于B组的58.1%和C组的60.6%（P〈0.05）。与治疗后B组比较,A组PAI-1,PAF,F1＋2降低,ACA,PS,PC,Fig,AT升高（P〈0.05）。与治疗后C组比较,A组FIB,D-D,LA,ACA,PAF,F1＋2,TAT降低,TT,PC,Fig,AT升高（P〈0.05）。A组总不良反应发生率3.1%,低于B组的38.7%和C组的30.3%（P〈0.05）。结论：滋肾健脾化瘀方可明显改善复发性流产脾肾两虚、血瘀阻络证患者临床症状和凝血功能,不良反应发生率低。Objective： To observe the effect of Zishen Jianpi Huayu prescription on the coagulation function of patients with recurrent spontaneous abortion with spleen and kidney deficiency and blood stasis resistance winding,in order to explore its mechanism. Method： A total of 115 eligible patients were randomly divided into group A,B and C,with 35 cases in each group. Zishen Jianpi Huayu prescription,aspirin tablets and low molecular weight heparin calcium were provided respectively. The scores of the traditional Chinese medicine（ TCM） syndrome differentiation spleen and kidney deficiency coalescing blood stasis（ TCM syndromes） and blood coagulation function [part of the original activators fibrinolytic enzyme inhibitor-1（ PAI-1）,activated partial thromboplastin time（ APTT）,thrombin time（ TT）,fibrinogen（ FIB）,tissue plasminogen activator（ t-PA）,prothrombin time（ PT）,D-dimer（ D-D）,tissue factor（ TF）,fibrin peptide A（ FPA）,lupus anticoagulant（ LA）,activated protein S（ PS）,activated protein C（ PC）,anti cardiolipin antibody（ ACA）,platelet aggregation function（ PAF）,fibrinogen（ Fig）,prothrombin-anti fibrinolytic prothrombin complex（ PAP）, prothrombin fragment（ F1 ＋ 2）,antithrombin（ AT）,thrombin-antithrombin time（ TAT） ] before and after treatment were observed. The effective rates and adverse reactions in each group were compared. Result： The total effective rate of group A was 84. 4%,which was higher than 58. 1% of group B and 60. 6% of group C（ P 〈0. 05）. Compared with group B,TCM syndrome score and coagulation function of group A were significantly improved（ P〈 0. 05）.To compare with group C,TCM syndrome score and coagulation function of group A were significantly improved（ P 〈0. 05）. The total adverse reaction rate of group A was 3. 1%,which was lower than 38. 7% of group B and30. 3% of group C（ P〈 0. 05）. Conclusion： Zishen Jianpi Huayu prescription can significantly alliviate the clinical symptoms and im

关 键 词：滋肾健脾化瘀方 复发性流产 凝血功能 脾肾两虚 血瘀阻络证 

分 类 号：R22[医药卫生—中医基础理论] R242[医药卫生—中医学]